Methods for preventing or treating bone disorders

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

Reexamination Certificate

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C530S324000, C530S325000

Reexamination Certificate

active

08008433

ABSTRACT:
The present invention relates to a method of preventing or treating a bone disorder in a mammal, comprising administering to the mammal a therapeutically effective amount of a peptide having ability to modulate lipid metabolism but having no appreciable effect on IGF-1.

REFERENCES:
patent: WO 01/04119 (2001-01-01), None
patent: WO 2004/033645 (2004-04-01), None
Degerblad M. (Acta Endocrinol 126, 387-93, 1992).
O'Halloran D.J. (J. Clin. Endocrinol. Metab. 76, 1344-48, 1993).
Johansson A. G (Journal of Clinical Endocrinology and Metabolism 81(1), 44-48, 1996).
Kamikovski et. al.: “Does the Growth Hormone-Derived Peptide AOD9604 Have an Anabolic Effect on bone?”, abstract, Bone 44 (2009) S211-S231 (1 pg).
English Translation of Notification of Reasons for Refusal in Japanese Patent Application No. 2007-511768 dated Mar. 15, 2011.
O. Ortoft et al., “Qualitative Alterations of Cortical Bone in Female Rats After Long-Term Administration of Growth Hormone and Glucocorticoid”, Bone, vol. 18, No. 6, Jun. 1995, pp. 581-590.
Claes Ohlsson et al., “Growth Hormone and Bone”, Endocrine Review, 19(1), pp. 55-79, 1998.
Andrea Giustina et al., “Effects of Recombinant Human Growth Hormone (GH) on Bone and Intermediary Metabolism in Patients Receiving Chronic Glucocorticoid Treatment with Supressed Endogenous GH Response to GH-Releasing Hormone”, Journal of Clinical Endocrinology and Metabolism, vol. 80, No. 1, pp. 122-129, 1996.

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