Methods for preparing solid supports for hybridization and reduc

Details Methods for preparing solid supports for hybridization and reduc Methods for preparing solid supports for hybridization and reduc

1996-10-17

1999-11-30

Marschel, Ardin H.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 4, 436501, 935 77, 935 78, C12Q 168

Patent

active

059940654

ABSTRACT:
Methods related to solid supports for binding reactions are disclosed. The present invention provides procedures for prepaing solid supports, and their use in binding assays, such that non-specific background on the solid supports is reduced. The reduction of non-specific background permits the detection of low levels of specific binding which normally would be masked by the non-specific binding. The methods are applicable to a variety of target ligands and probes, including nucleic acids such as oligonucleotides.

REFERENCES:
Van Ness et al., "A versatile solid support system for oligodeoxynucleotide probe-based hybridization assays," Nucleic Acid Research 19(12): 3345-3350, 1991.
Bresser et al. (1983) Proceedings of the National Academy of Sciences, USA, vol. 80, pp. 6523-6527.
Organic Chemistry (published by Allyn and Bacon, Inc., Boston, Massachasetts, 1973, authors Morrison and Boyd), pp. 658-670.
Bresser et al., DNA, vol. 2, No. 3, pp. 243-254, 1983.

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