Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Reexamination Certificate
2006-09-19
2006-09-19
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
C424S181100, C424S001890, C548S338100
Reexamination Certificate
active
07108846
ABSTRACT:
The present invention relates to chemical synthesis of radiolabelled perfluorinated bioactive compounds. More particularly, the present invention relates to radiolabelled compounds to be used as indicators for tissue hypoxia. More particularly, the present invention relates to the synthesis and the use of [18F] labelled perfluorinated nitroimidazole compounds having an incorporation of [18F] atoms characterized by a specific radioactivity of the compound comprised between 1 and 30 Ci/mmol, preferably between 1 and 20 Ci/mmol, preferably 1 and 10 Ci/mmol. More particularly to [18F] labelled EF3 or [18F] labelled EF5. The present invention also relates to a method for the detection of tissue hypoxia in a patient comprising introducing an [18F] labelled nitroimidazole compound into said patient, imaging tissue hypoxia in said patient, and, quantifying tissue hypoxia in said patient.
REFERENCES:
patent: 5540908 (1996-07-01), Koch et al.
patent: 5728843 (1998-03-01), Wallace et al.
patent: 5843404 (1998-12-01), Koch et al.
patent: 5886190 (1999-03-01), Wallace et al.
patent: WO94/11348 (1994-05-01), None
patent: WO95/09844 (1995-04-01), None
Kachur AV, et al. Synthesis of new hypoxia markers EF1 and [18F]-EF1. Applied Radiation and Isotopes. 1999;51:643-50.
J.B. Dickey et al., Fluorinated Aminoanthraquinon Dyes, Industrial and Engineering Chemistry, vol. 48, 1956, 209-213, XP-000874162, USA.
Olivier Josse et al, A Convenient Synthesis of Ethyl 3-Aminopropanedithioate (Beta-Alanine Ethyl Dithioester) Synthesis, Mar. 1999, 404-406, XP-002129104, Germany and USA.
Gregoire Vincent
Marchand Jacqueline
Sackey Ebenezer
Solola Taofiq
Universite Catholique De Louvan
LandOfFree
Methods for preparing perfluorinated [ 18 f]-radiolabelled... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for preparing perfluorinated [ 18 f]-radiolabelled..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for preparing perfluorinated [ 18 f]-radiolabelled... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3616408