Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-07-24
2000-03-14
Fonda, Kathleen K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 185, 5361231, C08B 3700, C07H 100
Patent
active
060374675
ABSTRACT:
Carbohydrate-containing polymers which can have an HLB* of from about 10 to about 20 are disclosed. The compounds comprise a hydrophilic polymer portion, a carbohydrate portion comprising from 1 to about 20 naturally occurring, identical or different, monosaccharide units, at least one bifunctional spacer coupling the carbohydrate portion to the hydrophilic polymer portion, and a potentiator moiety. The potentiator moiety can be is a crosslinking moiety located within the hydrophilic polymer or a hydrophobic, hydrophilic or ionic moiety. Processes for the preparation and use of such polymers are also disclosed.
REFERENCES:
patent: 4804542 (1989-02-01), Fischer et al.
patent: 4868289 (1989-09-01), Magnusson et al.
patent: 5041291 (1991-08-01), Bader et al.
patent: 5059654 (1991-10-01), Hou et al.
patent: 5219926 (1993-06-01), Lindman et al.
patent: 5241072 (1993-08-01), Colon et al.
patent: 5280016 (1994-01-01), Conrad et al.
patent: 5329028 (1994-07-01), Ashkenazi et al.
patent: 5395924 (1995-03-01), Blattler et al.
T. Feizi et al., "Carbohydrates as antigenic determinants of glycoproteins", Biochem. J. 245:1-11 (1987).
Stults et al., "Glycosphingolipids: Structure, Biological Source, and Properties", Methods in Enzymology 179:167 (1989).
Hakomori, "Aberrant Glycosylation in Tumors and Tumor-Associated Carbohydrate Antigens", Adv. Cancer Res. 52-257 (1989).
Bevilacqua et al., "Endothelial Leukocyte Adhesion Molecule-1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins", Science, 243:1160-1165 (1989).
Connolly et al., "Binding and Endocytosis of Cluster Glycosides by Rabbit Hepatocytes", J. Biol. Chem. 257(2):939-945 (1982).
Spaltenstein et al., "Polyacrylamides Bearing Pendant .alpha.-Sialoside Groups Strongly Inhibit Agglutination of Erythrocytes by Influenza Virus", J. Am. Chem. Soc. 113-686-687 (1991).
Yamazaki et al., "Studies on Carbohydrate Binding Proteins Using Liposome-Based Systems-I. Preparation of Neoglycoprotein-Conjugated Liposomes and the Feasibility of Their Use as Drug-Targeting Devices", Int. J. Biochem. 24(1):99-104 (1992).
R. Rathi et al., "N-(2-Hydroxypropyl) methacrylamide Copolymers Containing Pendant Saccharide Moieties: Synthesis and Bioadhesive Properties", J. Polym. Sci. 29:1985-1902 (1991).
Pitka et al., "Interaction of Macromolecular Drugs with Beta-Adrenoceptors", Annals New York Academy of Science 446:249-257 (1985), months not available.
S. Nishimura et al., "Synthetic Glycoconjugates 2..sup.1 n-Pentenyl Glycosides and Convenient Mediators for the Syntheses of New Types of Glycoprotein Modelsl", Macromolecules:4236-4241 (1991), months not available.
Spellman et al. Biochemistry Feb. 19, 1991, 30, 2395-2406.
Ahlers Michael
Bartnik Eckhart
Grabley Susanne
Kretzschmar Gerhard
Schleyerbach Rudolf
Fonda Kathleen K.
Glycorex AB
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