Methods for preparing antiproliferative 5-substituted pyrimidone

Details Methods for preparing antiproliferative 5-substituted pyrimidone Methods for preparing antiproliferative 5-substituted pyrimidone

1995-05-24

1998-03-10

Gupta, Yogendra N.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544298, 544321, C07D23948

Patent

active

057263124

ABSTRACT:
Intermediates for preparing derivatives of 5-thia- and 5-selenopyrimidinone, ##STR1## which are useful as inhibitors of the enzymes glycinamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase (AICARFT). The present invention is also directed to methods of preparing these intermediates.

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