Methods for preparing 3-[N-phenyl-acetylaminopiperidine]-2,6-dio

Details Methods for preparing 3-[N-phenyl-acetylaminopiperidine]-2,6-dio Methods for preparing 3-[N-phenyl-acetylaminopiperidine]-2,6-dio

1989-01-11

1990-04-17

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514328, C07D21140

Patent

active

049181939

ABSTRACT:
Disclosed is a process for synthesizing 3-[N-phenylacetylaminopiperidine]-2,6-dion, which process comprises the steps of providing a quantity of L-glutamine, providing a quantity of phenylacetyl halide, mixing together the L-glutamine and phenylacetyl halide in a weakly alkaline aqueous solution to provide an aqueous reaction mixture, adjusting the reaction mixture to a pH ranging from about 2 to about 3, and recovering from the reaction mixture the product 3-[N-phenylacetylamino-piperidine]-2,6-dion, and when desired preparing the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4558057 (1985-12-01), Burzynski
Burzynski, "Synthetic Antineoplastons and Analogs", Drugs of the Future, 11:679-688, (1986).
Burzynski, "Antineoplaston A10", Drugs of the Future, 10:103-105, (1985).

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