Methods for preparing 1-deoxy paclitaxels

Details Methods for preparing 1-deoxy paclitaxels Methods for preparing 1-deoxy paclitaxels

1997-04-14

1998-04-14

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549510, 549511, C07D30908, C07D30514

Patent

active

057393591

ABSTRACT:
The present invention provides methods for making a novel class of 1-deoxy paclitaxel derivatives. These derivatives include 1-deoxy paclitaxel. The derivatives of the present invention are potent cytotoxic agents.

REFERENCES:
Ojima et al., "New and Efficient Approaches to the Semisynthesis of Taxol and Its C-13 Side Chain Analogs by Means of .beta.-Lactam Synthon Methods" Tetrahedron (1992) 48:6985-7012, No. 34.
Brieva et la., "Chemoenzymatic Synthesis of the C-13 Side Chain of Taxol: Optically-Active 3-Hydroxy-4-phenyl .beta.-Lactam Derivatives" J. Org. Chem. (1993) 58:1068-1075, No. 5.
S.H. Chen, "The Chemistry of Taxanes: Skeletal Rearrangements of Baccatin Derivatives via Radical Intermediates," J. Org. Chem. (1994) 56:1475-1484.
A.G. Chaudhary et al., "A Novel Benzoyl Group Migration: Synthesis and Biological Evaluation of 1-Benzoyl-2-des(benzoyloxy)paclitaxel," J. Org. Chem. (1995) 60:3260-3262.

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