Methods for preparing 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidi

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544364, 544372, C07D40106, C07D40114, C07D40306

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active

060840978

ABSTRACT:
The invention relates to a process for the synthesis of 1-[4-Arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes used as potential therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders, having general formula 1 ##STR1## wherein Ar represents a phenyl ring substituted by the groups like halo, alkoxy, alkyl or heteroaryl, n=1 or n=2; a process of preparing said compounds and a method of treating hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders.

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patent: 4745117 (1988-05-01), Ishizumi et al.
patent: 5077295 (1991-12-01), Bright et al.
patent: 5599815 (1997-02-01), Fukuda et al.

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