Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process...
Reexamination Certificate
2007-10-09
2007-10-09
Nashed, Nashaat T. (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
C435S068100, C435S135000
Reexamination Certificate
active
10017324
ABSTRACT:
The preparation of macrocyclic molecules from linear, synthetic thioester precursors is disclosed. An excised thioesterase domain isolated from either a polyketide synthases (PKS) or non-ribosomal peptide synthetases (NRPS) multido system catalyzes the cyclization reaction. Thioester substrates also are described that are efficiently cyclized by the method of the present invention. Additionally, macrocyclic molecules, including macrolactones and macrolactams, that are prepared by the macrocyclization methods of the invention are described.
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Burkart Michael D.
Kohli Rahul Manu
Maraheil Mohammed A.
Mootz Henning Dieter
Schwarzer Dirk
Edwards Angell Palmer & & Dodge LLP
Nashed Nashaat T.
Neuner George W.
President and Fellows of Harvard College
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