Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1982-07-26
1984-02-28
Schain, Howard E.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424 89, A61K 3912, A61K 3942, A61K 3706, C07G 700
Patent
active
044340931
ABSTRACT:
Methods for producing from human serum, human gamma globulin essentially free of HB.sub.s Ag and products resulting therefrom. Specifically provided are ion exchange resin/buffer systems capable of effectively removing HB.sub.s Ag thought to be closely correlated with viral hepatitis type B infectivity. Additional steps can include ultrafiltration to increase reduction of any virus not removed in the column passage as well as the addition of anti-HB.sub.g to substantially eliminate all infectivity.
REFERENCES:
patent: 2761811 (1956-09-01), Kupferberg
patent: 3073747 (1963-01-01), Reid
patent: 3197374 (1965-07-01), Hennessen
patent: 3234199 (1966-02-01), Reid
patent: 3664994 (1972-05-01), Perper
patent: 3794584 (1974-02-01), Kenin
patent: 3917527 (1975-11-01), Shaltiel
patent: 4136094 (1979-01-01), Condie
patent: 4162192 (1979-07-01), Mizuno et al.
patent: 4165370 (1979-08-01), Coval
patent: 4168300 (1979-09-01), Andersson et al.
patent: 4181713 (1980-01-01), McAleer et al.
patent: 4276283 (1981-06-01), Eibl et al.
patent: 4296027 (1981-10-01), Condie
patent: 4349539 (1982-09-01), Wampler
Tiollais, P. et al., Biology of Hepatitis B Virus, Science, vol. 213, 406-411, Jul. 1981.
Blumberg, B. S. et al., Australia Antigen and Hepatitis, CRC Monotopic Series, CRC Press, Cleveland, Ohio, 1982.
Gerety, R. J. et al., Tests for HBV-Associated Antigens and Antibodies, Chapter 11 of Viral Hepatitis, Ed. Vyas et al., The Franklin Institute Press, Philadelphia, PA, 1978.
Baumstark, J. S. et al., A Preparative Method for the Separation of 7S Gamma Globulin from Human Serum, Archives of Biochemistry and Biophysics 108:514-522, (1964).
Webb, A. J., A 30-Minute Preparative Method for Isolation of IgG from Human Serum, Vox Sang 23:279-290, (1972).
Stanworth, D. R., A Rapid Method of Preparing Pure Serum Gamma-Globulin.
Hoppe, H. H. et al., Prevention of Rh-Immunization, Modified Production of IgG Anti-Rh for Intravenous Application by Ion Exchange Chromatography, Vox Sang 25:308-316, (1973).
Friesen, A. D. et al., Column Ion-Exchange Preparation and Characterization of an Rh Immune Globulin for Intravenous Use, J. Applied Biochem. 3:164-175, (1981).
Johnson, A. J. et al., Removal of Hepatitis B Surface Antigen from Plasma Fractions, J. Laboratory and Clinical Medicine, 88, No. 1:91-101, Jul. 1976.
Nature, 188, 156-157, (1960), Stanworth.
Vox Sang 25:308-316, (1973), Hoppe et al.
J. of Applied Biochem. 3 (164-175), 1981, Friesen et al.
Arch. of Biochem. and Biophysics, 108, 514-522, (1964), Baumstark et al.
Kaplan Paul M.
Padvelskis John V.
Zolton Raymond P.
Hofer Mark A.
Ortho Diagnostic Systems Inc.
Schain Howard E.
LandOfFree
Methods for preparation of HB.sub.s Ag free gamma globulins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for preparation of HB.sub.s Ag free gamma globulins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for preparation of HB.sub.s Ag free gamma globulins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-758599