Methods for preparation of 1,2-dihydroquinolines

Details Methods for preparation of 1,2-dihydroquinolines Methods for preparation of 1,2-dihydroquinolines

1998-05-27

2000-07-25

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546181, 556410, C07D47100, C07D49100, C07D49800, C07D51300

Patent

active

060938250

ABSTRACT:
Methods for conversion of anilines to 1,2-dihydroquinolines. 1,2-dihydroquinoliiies are generated from combining an aniline, a silylating agent, and further condensing with a ketone in the presence of a catalyst. In one aspect, the silylation of the aniline may be performed in a one-step synthesis by adding the silylating, agent to the same reaction vessel as the ketone, aniline, and catalyst. In a second aspect, the 1,2-dihydroquinoline is generated in a two-step synthesis where an N-silyl aniline is formed prior to the addition of the ketone and catalyst.

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