Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1995-06-07
1998-08-04
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
A61K 3159
Patent
active
057893977
ABSTRACT:
1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
REFERENCES:
patent: 3880894 (1975-04-01), DeLuca et al.
patent: 4022891 (1977-05-01), Takeshita et al.
patent: 4159326 (1979-06-01), Barton et al.
patent: 4195027 (1980-03-01), DeLuca
patent: 4338250 (1982-07-01), DeLuca
patent: 4670190 (1987-06-01), Hesse et al.
patent: 4719205 (1988-01-01), DeLuca et al.
patent: 5098899 (1992-03-01), Gilbert et al.
R. Belsey, H. F. DeLuca and J. T. Potts, Jr., Rapid Communications, pp. 554-557 (1971).
E. G. Bligh and W. J. Dyer, Canadian Journal of Biochemistry and Physiology, vol. 37, pp. 911-917 (1959).
Harrison's Priciples of Internal Medicine: Part Seven, "Disorders of Bone and Mineral Metabolism: Chap. 35," in E. Braunwald, K. J. Isselbacher, R. G. Petersdorf, J. D. Wilson, J. B. Martin and H. S. Fauci (eds.), Calcium, Phosphorous and Bone Metabolism: Calcium Regulating Hormones, McGraw-Hill, New York, pp. 1860-1865.
H. F. DeLuca and V. K. Ostrem, Prog. Clin. Biol. Res., vol. 259, pp. 41-55 (1988).
M. F. Holick, A. Kleiner-Bossallier, H. K. Schnoes, P. M. Kasten, I. T. Boyle and H. F. DeLuca, J. Biol. Chem., vol. 248, pp. 6691-6696 (1973).
B. W. Hollis, Clin. Chem., vol. 32, No. 11, pp. 2060-2063 (1986).
R. L. Horst, N. J. Koszewski and T. A. Reinhardt, Biochem., vol. 29, pp. 578-582 (1990).
S. Ishizuka, K. Bannai, T. Naruchi and Y. Hashimoto, Steroids, vol. 37, No. 1, pp. 33-42 (1981).
S. Ishizuka, K. Bannai, T. Naruchi and Y. Hashimoto, Steroids, vol. 39, No. 1, pp. 53-62 (1982).
G. Jones, Clin. Chem., vol. 24, No. 2, pp. 287-298 (1978).
G. Jones, A. Rosenthal, D. Segev, Y. Mazur, F. Frolow, Y. Halfon, D. Rabinovich, and Z. Shakked, Biochemistry, vol. 18, No. 6, pp. 1094-1101 (1979).
G. Jones, H. K. Schnoes, L. Levan and H. F. DeLuca, Archives of Biochemistry and Biophysics, vol. 202, No. 2, pp. 450-457 (1980).
H. E. Paaren, H. F. DeLuca and H. K. Schnoes, J. Org. Chem., vol. 45, pp. 3253-3258 (1980).
J. G. Rheinwald and H. Green, Cell, vol. 6, pp. 331-343 (1975).
H. L. Shieh, J. M. Pezzuto and G. A. Cordell, Chem.-Biol. Interact., vol. 81, pp. 35-55 (1992).
S. Strugnell, M. J. Calverley and G. Jones, Biochemical Pharmacology, vol. 40, pp. 333-341 (1990).
S. Tam, S. Strugnell, R. G. Deeley and G. Jones, Journal of Lipid Research, vol. 29, pp. 1637-1642 (1988).
Calcium Regulation and Bone Metabolism Basic and Clinical Aspects, vol. 9 in R. L. Horst, N. A. Koszewski and T. A. Reinhardt, Quantitation and Biological Evaluation of the C-24 Hydroxylation Pathway of Vitamin D., Excerpta Medica, Amsterdam-New York-Oxford, p. 598 1987.
Analytical Biochemistry, vol. 162, 1987,N. J. Koszewski, T. A. Reinhardt, D. C. Beitz, J. L. Napoli, E. G. Baggiolini, M. R. Uskokohivc, and R. L. Horst, "Use of Fourier Transform .sup.1 H NMR in the Identification of Vitamin D.sub.2 Metabolites", pp. 446-452.
Bishop Charles W.
Guo Liang
Horst Ronald L.
Jones Glenville
Knutson Joyce C.
Bone Care International, Inc.
Dees Jos,e G.
Pryor Alton
Welch Teresa J.
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