Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-02-27
2011-12-06
Goldberg, Jeanine A (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S006110, C435S091100, C435S091200, C536S023100, C536S024300
Reexamination Certificate
active
08071299
ABSTRACT:
The present invention relates to a method of diagnosing a predisposition of a multiple sclerosis (MS) patient for responsiveness to a treatment of MS by administration of interferon-α (IFN-α) and/or interferon-β (IFN-β) and means to perform the method. Furthermore, the invention relates to a method of diagnosing a predisposition of a patient for developing multiple sclerosis (MS) and corresponding means.
REFERENCES:
patent: 2005/054810 (2005-06-01), None
Leyva, Laura, et al., IFNARI and IFNAR2 Polymorphisms Confer Susceptibility to Multiple Sclerosis but not to Interferon-beta Treatment Response, Journal of Neuroimmunology 163:165-171 (2005).
Martinez Doncel, Alfonso, et al., Interleukin-10 Polymorphisms in Spanish Multiple Sclerosis Patients, Journal of Neuroimmunology, 131:168-172 (2002).
Mihailova, Snejina, et al., Pro- and Anti-Inflammatory cytokine Gene Polymorphism Profiles in Bulgarian Multiple Sclerosis Patients, Journal of Neuroimmunology, 168:138-143 (2005).
Sriram, U., et al., Pharmacogenomic Analysis of Interferon Receptor Polymorphisms in Multiple Sclerosis, Genes and Immunity 4:147-152 (2003).
Swanberg, Maria, et al., MHC2TA is Associated with Differential MHC Molecule Expression and Susceptibility to Rheumatoid Arthritis, Multiple Sclerosis and Myocardial Infarction, Nature Genetics, 37(5):486-494 (2005).
Wergeland, S., et al., IL-10 Promoter Haplotype Influence on Interferon Treatment Response in Multiple Sclerosis, European Journal of Neurology, 12:171-175 (2005).
Holsboer Florian
Lucae Susanne
Muller-Myhsok Bertram
Salyakina Daria
Uhr Manfred
Goldberg Jeanine A
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.
Pillsbury Winthrop Shaw & Pittman LLP
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