Methods for predicting the efficacy of a chemotherapeutic regime

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 723, 435 75, 435 792, 5303871, 5303911, 530350, G01N 3353, C07K 100, C07K 1600

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active

059981512

ABSTRACT:
Methods for determining whether a chemotherapeutic treatment is appropriate for patients afflicted with gastrointestinal cancers, comprising;

REFERENCES:
Kevomarsi et al (J. Cell Biol. 115 (3pt2):206A, 1991.
Peters et al (J. Clin Oncol, 12:2035-2042), 1994.
Drake et A (AntiCancer Drugs 4:431-435, 1993.
Ajani, Jaffer, A., et al. (1991) "Resectable Gastric Carcinoma", Cancer 68(7):1501-1506.
Alexander, H. Richard, et al. (1995) "Thymidylate Synthase Protein Expression", The Cancer Journal from Scientific American, 1(1):49-54.
Chu, Edward, et al. (1990) "Interaction of .gamma. Interferon and 5-Fluorouracil in the H630 Human Colon Carcinoma Cell Line", Cancer Research 50:5834-5840.
Elledge, R.M., et al. (1994) "Evaluation of thymidylate synthase RNA expression by polymerase chain reaction", Molecular and Cellular Probes 8:67-72.
Johnston, Patrick G., et al. (1991) "Production and Characterization of Monoclonal Antibodies That Localize Human Thymidylate Syntase in the Cytoplasm of Human Cells and Tissue", Cancer Research 51:6668-6676.
Johnston, Patrick G., et al. (1992) "Immunological Quantitation of Thymidylate Synthase Using the Monoclonal Antibody TS 106 in 5-Fluorouracil-sensitive and--resistant Human Cancer Cell Lines", Cancer Research 52:4306-4312.
Johnston, Patrick G., et al. (1994) "The Role of Thymidylate Synthase Expression in Prognosis and Outcome of Adjuvant Chemotherapy in Patients with Rectal Cancer", Journal of Clinical Oncology, 12(12):2640-2647.
Johnston, Patrick G., et al. (1995) "Thymidylate Synthase Gene and Protein Expression Correlate and Are Associated with Response to 5-Fluorouracil in Human Colorectal and Gastric Tumors", Cancer Research 55:1407-1412.
Kelsen, David, et al. (1992) "FAMTX Versus Etoposide, Doxorubicin, and Cisplatin: A Random Assignment Trial in Gastric Cancer", Journal of Clinical Oncology 10(4):541-548.
Silberman, L. Leichman, et al. (1992) "Preoperative Systemic Chemotherapy Followed by Adjuvant Postoperative Intraperitoneal Therapy for Gastric Cancer: A University of Southern California Pilot Program", Journal of Oncology 10(2):1933-1942.
Lerner, Adam, et al. "Etoposide, Doxorubicin, and Cisplatin Chemotherapy for Advanced Gastric Adenocarcinoma: Results of a Phase II Trial", Journal of Oncology, 10(4):536-540.
Romain, Sylvie, et al. (1997) "DNA-Synthesis Enzyme Activity: A Biological Tool Useful for Predicting Anti-Metabolic Drug Sensitivity in Breast Cancer?", Int. J. Cancer (Pred. Oncol)74:156-161.
Swain, S.M., et al. (1989) "Flurouracil and High-Dose Leucovorin in Previously Treated Patients with Metastatic Breast Cancer", Journal of Clinical Oncology 7(7):890-899.
Wilke, H., et al. (1989) "Preoperative Chemotherapy in Locally Advanced and Nonresectable Gastric Cancer: A Phase II Study with Etoposide, Doxorubicin, and Cisplatin", Journal of Clinical Oncology, 7(():1318-1326.
Keyomarsi, K., et al. (1991) "Differential Expression of Thymidylate Synthase Message Versus Protein in Synchronized Human Breast Cancer Cells", J. Cell Biol. 115 (3 Part 2): 206A.
Kang, Y.K. et al. (1992) "The Effect of Neoadjuvant Chemotherapy on the Surgical Outcome of Locally Advanced Gastric Adenocarcinoma: Interim Report of a Randomized Controlled Trial", Proceedings of ASCO 11:173 (505).
Johnston, P.G., et al. (1994) "Thymidylate Syntase Protein and Gene Expression Predicts for Response to 5-Fluorouracil Leucovorin Chemotherapy in Patients with Colorectal and Gastric Cancer", Proceedings of ASCO 13:196 (569).
Ajani, J.A., et al. (1992) "Preoperative and Postoperative Chemotherapy (CT) for Patients with Potentially Resectable Gastric Carcinoma", Proceedings of ASCO 11:165 (475).

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