Methods for predicting irinotecan toxicity

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091200, C536S025320, C514S283000

Reexamination Certificate

active

07807350

ABSTRACT:
The present invention concerns the methods and compositions for evaluating the risk of ironotecan toxicity in a cancer patient based on the genotype of the patient at position −3156 of the UGT1A1 gene or at any position in linkage disequilibrium with the −3156 variant.

REFERENCES:
patent: 5786344 (1998-07-01), Ratain et al.
patent: 5972614 (1999-10-01), Ruano et al.
patent: 6066645 (2000-05-01), Hausheer et al.
patent: 6287834 (2001-09-01), Belanger et al.
patent: 6319678 (2001-11-01), Trubetskoy et al.
patent: 6395481 (2002-05-01), Di Rienzo et al.
patent: 6407117 (2002-06-01), Bouscarel et al.
patent: 6448003 (2002-09-01), Guida et al.
patent: 6472157 (2002-10-01), Di Rienzo et al.
patent: 6479236 (2002-11-01), Penny et al.
patent: 6586175 (2003-07-01), Galvin et al.
patent: 2002/0061518 (2002-05-01), Penny et al.
patent: 2003/0077629 (2003-04-01), Galvin et al.
patent: 2003/0099960 (2003-05-01), Ratain et al.
patent: 2003/0099977 (2003-05-01), Guida et al.
patent: 2003/0157517 (2003-08-01), Penny et al.
patent: 2004/0058363 (2004-03-01), Hasegawa et al.
patent: 2004/0076968 (2004-04-01), Acuna et al.
patent: 2004/0121327 (2004-06-01), Manns et al.
patent: 2004/0203034 (2004-10-01), Ratain et al.
patent: 0919244 (1999-06-01), None
patent: 1352970 (2003-10-01), None
patent: 2004-073035 (2004-03-01), None
patent: WO 94/22846 (1994-10-01), None
patent: WO 95/08986 (1995-04-01), None
patent: WO 96/01127 (1996-01-01), None
patent: WO 97/32042 (1997-09-01), None
patent: WO 99/57322 (1999-11-01), None
patent: WO 00/06776 (2000-02-01), None
patent: WO 01/79230 (2001-10-01), None
patent: WO 02/06523 (2002-01-01), None
patent: WO 02/053770 (2002-07-01), None
patent: WO 02/057410 (2002-07-01), None
patent: WO 03/013536 (2003-02-01), None
patent: WO 03/013537 (2003-02-01), None
patent: WO 2004/016814 (2004-02-01), None
Ruano, G. et al. Nucleic Acids Research 19(24):6877-6882 (1991).
Abraham et al., “Non-glucocorticoid steriod analogues (21-aminosteroids) sensitize multidrug resistant cells to vinblastine,”Cancer Chemother. Pharmacol., 32(2):116-122, 1993.
Akiyama et al., “Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of p-glycoprotein by a vinblastine analog,”Mol. Pharmacol., 33(2):144-147, 1988.
Ando et al., “Polymorphisms of UDP-Glucuronsyltransferase Gene and Irinotecan Toxicity: A Pharmacogenetic Analysis,”Cancer Res., 60(24):6921-6926, 2000.
Ando et al., “UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan,”Annals of Oncology, 9:845-847, 1998.
Ansher et al., “Chemoprotective effects of two dithiolthiones and of butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity,”Hepatology, 3(6):932-935, 1983.
Araki et al., “Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and blood plasma of athymic mice following intraperitoneal administration of CPT-11,”Jpn J. Cancer Res., 84:697-702, 1993.
Ariyoshi et al., “Mouse-human chimeric antibody MH171 against the multidrug transporter P-glycoprotein,”Jpn. J. Cancer Res., 83(5):515-521, 1992.
Atsumi et al., “Identification of the Metabolites of Irinotecan, a New Derivative of Camptothecin, in Rat Bile and its Biliary Excretion,”Xenobiotica, 21(9):1159-1169, 1991.
Barbier et al., “3′-azido-3′-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 3B7 (UGT2B7),”Drug Metab. Dispos., 28:497-502, 2000.
Barker et al., “Determination of plasma concentrations of epirubicin and its metabolites by high-performance liquid chromatography during a 96-h infusion in cancer chemotherapy,”J Chromatogr B Biomed Appl, 681:323-329, 1996.
Bear, “Drugs transported by-P-glycoprotein inhibit a 40pS outwardly rectifying chloride channel,”Biochem. Biophys. Res. Commun., 200(1):513-521, 1994.
Bell et al., “Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin,”Biochem. Pharmacol., 48(3):495-503, 1994.
Bertrand et al.., “Sequential Administration of Camptothecin and Etoposide Circumvents the Antagonistic Cytotoxicity of Simultaneous Drug Administration in Slowly Growing Human Colon Carcinoma HT-29 Cells,”Eur. J. Cancer, 28A(4-5):743-748, 1992.
Beutler et al., “Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism,”PNAS USA, 95:8170-8174, 1998.
Bhasker et al., “Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance,”Pharmacogenetics, 10(8):679-685, 2000.
Bible and Kaufmann, “Cytotoxic synergy between flavopiridol (NSSC 649890, L86-8275) and various antineoplastic agents: the importance of sequence of administration,”Cancer Res., 57:3375-3380, 1997.
Bible and Kaufmann, “Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells,”Cancer Res., 56:4856-4861, 1996.
Bock et al., “Purification of Rat Liver UDP-Glucuaronyltransferase: Separation of Two Enzyme Forms with Different Substrate Specificity and Differential Inducibility,” In: Conjugation reactions in biotransformation, Elsevier, North Holland Biomedical Press, p. 357-364, 1978.
Boesch and Loor, “Extent and persistence of P-glycoprotein inhibition in multidrug-resistant P388 cells after exposure to resistance-modifying agents,”Anticancer Drugs, 5(2):229-238, 1994.
Boesch et al., “Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative,”Exp. Cell. Res., 196(1):26-32, 1991.
Boiteux-Antoine et al., “Comparative induction of drug-metabolizing enzymes by hypolipidaemic compounds,”Gen-Pharmacol, 20(4):407-412, 1989.
Bosma et al., “Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar Syndrome, Type I,”Hepatology, 15:941-947, 1992.
Bosma et al., “The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome,”New England Journal of Medicine, 333:1171-1175, 1995.
Burchell and Coughtrie, “UDP-glucuronosyltransferases,”Pharmac. Ther., 43:261-289, 1989.
Burchell et al., “The UDP Glucuronosyltransferase gene suprefamily: suggested nomenclature based on evolutionary divergence,”DNA Cell Biol., 10:487-494, 1991.
Burger et al., “Pharmacokinetic interaction between rifampin and zidovudine,”Antimicrobial Agents and Chemotherapy, 37(7):1426-1431, 1993.
Campain et al., “Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II,”J. Cell Physiol., 155(2):414-425, 1993.
Carlson et al., “Flavopiridol induces G1arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells,”Cancer Res, 56:2973-2978, 1996.
Carrier et al., “Isolation and characterization of the human UGT2B7 gene,”Biochem and Biophys. Res. Commun., 272:616-621, 2000.
Cascorbi et al., “Frequency of single nucleotide polymorphisms in the p-glycoprotein drug transporter MDR1 gene in white subjects,”Clinc. Pharmacol Ther., 69:169-174, 2001.
Charuk et al., “Interaction of Rat Kidney P-Glycoprotein with a Urinary Component and Various Drugs Including Cyclosporin A,”Am. J. Physiol., 266:F66-F75, 1994.
Chen and Okayama, “Calcium phosphate-mediated gene transfer: A highly efficient transfection system for stably transforming cells with plasmid DNA,”Biotechniques, 6:632-638,

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