Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2004-11-23
2008-08-19
Switzer, Juliet C (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200
Reexamination Certificate
active
07413861
ABSTRACT:
The present invention provides a method for predicting whether a patient having varicocele-associated infertility will have an increase in sperm in the ejaculate after varicocele repair surgery. In the method of the present invention, the present or absence of undelete forms of exons6, 7, 8and9the patient's L-VDCC α1c transcript is detected. The presence of undeleted forms of the exons indicates that varicocele repair surgery will result in increased ejaculate, and the absence of undeleted forms of the exons indicates that varicocele repair surgery will not result in increased ejaculate.
REFERENCES:
Goodwin et al. Molecular Human Reproduction, vol. 6, No. 2, pp. 127-236, Feb. 2000.
Benoff Susan
Goodwin Leslie
Hurley Ian R.
Pergolizzi Robert G.
Amster Rothstein & Ebenstein LLP
Switzer Juliet C
The Feinstein Institute for Medical Research
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