Methods for parallel synthesis of organic compounds

Details Methods for parallel synthesis of organic compounds Methods for parallel synthesis of organic compounds

1997-10-10

2000-04-18

Ludlow, Jan

Chemistry: analytical and immunological testing

Including sample preparation

Liberation or purification of sample or separation of...

422 99, 422101, 4352971, 4352975, 436 89, 436174, B01L 102, B01L 700

Patent

active

060514396

ABSTRACT:
The invention provides a method for synthesizing various chemicals onto solid supports, cleaving the synthesized compounds and preparing samples for analysis. In one exemplary embodiment, the invention provides a device comprising a housing which defines an enclosure. A plate having a plurality of wells is received into the enclosure. Each of the wells has a bottom end and at least some of the wells have a hole in the bottom end. A pressure source is in fluid communication with the holes in the bottom ends of the wells. In this manner, a fluid may be maintained within the wells by application of pressure from the pressure source.

REFERENCES:
patent: 4111754 (1978-09-01), Park
patent: 4493815 (1985-01-01), Fernwood et al.
patent: 4526690 (1985-07-01), Kiovsky et al.
patent: 4598049 (1986-07-01), Zelinka et al.
patent: 4894343 (1990-01-01), Tanaka et al.
patent: 4948442 (1990-08-01), Manns
patent: 5047215 (1991-09-01), Manns
patent: 5108704 (1992-04-01), Bowers et al.
patent: 5147608 (1992-09-01), Hudson et al.
patent: 5183744 (1993-02-01), Kawamura et al.
patent: 5186844 (1993-02-01), Burd et al.
patent: 5219528 (1993-06-01), Clark
patent: 5272081 (1993-12-01), Weinreb et al.
patent: 5273718 (1993-12-01), Skould et al.
patent: 5288464 (1994-02-01), Nokihara
patent: 5308757 (1994-05-01), Kawamura et al.
patent: 5324483 (1994-06-01), Cody et al.
patent: 5355686 (1994-10-01), Weiss
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5457527 (1995-10-01), Manns et al.
patent: 5472672 (1995-12-01), Brennan
patent: 5503805 (1996-04-01), Sugarman et al.
patent: 5506141 (1996-04-01), Weinreb et al.
patent: 5516491 (1996-05-01), Kath et al.
patent: 5529756 (1996-06-01), Brennan
patent: 5565324 (1996-10-01), Still et al.
patent: 5585275 (1996-12-01), Hudson et al.
patent: 5599688 (1997-02-01), Grass
patent: 5604130 (1997-02-01), Warner et al.
patent: 5609826 (1997-03-01), Cargill et al.
patent: 5620894 (1997-04-01), Barger et al.
patent: 5622699 (1997-04-01), Ruoslahti et al.
patent: 5639428 (1997-06-01), Cottingham
patent: 5650489 (1997-07-01), Lam et al.
patent: 5665975 (1997-09-01), Kedar
patent: 5688696 (1997-11-01), Lebl
patent: 5712171 (1998-01-01), Zambias et al.
patent: 5725831 (1998-03-01), Reichler et al.
patent: 5770157 (1998-06-01), Cargill et al.
patent: 5792430 (1998-08-01), Hamper
patent: 5888830 (1999-03-01), Mohan et al.
This reference is a picture of HP 7686 Solution-Phase Synthesizer by Hewlett Packard.
This reference is a picture of a MultiReactor.TM. Synthesizer by RoboSynthon, Inc.
This reference is a picture of a Stem Reacto-Stations.TM. Synthesizer by Stem Coporation.
This reference is a picture of an RS 1000 with air-cooled reflux module.
This reference is a picture of a RAM.TM. Synthesizer.
This reference is a picture of a Nautilus.TM. 2400 Synthesizer by Argonaut Technologies, Inc.
This reference is a picture of a Model 496 Multiple Organic Synthesizer by Advanced Chem Tech.
This reference is a picture of MicroKans.RTM. and Microtubes.RTM. by IRORI. These are used in an AccuTag.RTM.100 Combinatorial Chemistry System by IRORI.
This reference is a picture of an AutoSort.RTM.-10K Microreactor Sorting System by IRORI.
This reference is a picture of SOPHAS M Solid Phase Synthesizer by Zinsser Analytic.
This reference is a picture of a Quest 210 Synthesizer by Argonaut Technolgies.
This refers to pictures of an APOS 1200 Synthesizer by Rapp Polymere GmbH.
Baiga (1998), "Integrated Instrumentation for High-Throughput Organic Synthesis," Presented at Cambridge Healthtech Institute's Third Annual Symposium "High-Throughput Organic Synthesis", Mar. 5-6, Coronodo, California.
Baldwin et al. (1995), "Synthesis of a Small Molecule Library Encoded with Moelcular Tags," J. Am. Chem. Soc. 117:5588-5589.
Bergot (1998), "Combinatorial Chemistry Workstation to Facilitate Pharmaceutical Development," Presented at Cambridge Healthtech Institute's Third Annual Symposium "High-Throughput Organic Synthesis", Mar. 5-6, Coronodo, California.
Brenner and Lerner (1992), "Encoded combinatroial chemistry," Proc. Natl. Acad. Sci. U.S.A. 89:5381-5383.
Campbell (1998), "Automating Solid-Phase Synthesis without Compromise," Presented at Cambridge Healthtech Institute's Third Annual Symposium "High-Throughput Organic Synthesis," Mar. 5-6, Coronodo, California.
Cargill et al. (1995), "Automated Combinatorial Chemistry on Solid Phase," Proceedings of the International Symposium on laboratory Automation and Robotics 1995. Zymark Corporation, Zymark Center, Hopkinton, MA, pp. 221-234.
Cargill et al. (1996), "Automated Combinatorial Chemistry on Solid Phase," Laboratory Robotics and automation, 8:139-148.
Czarnik, A.W. (1997) No static at all: using radiofrequency memory tubes without (human) interference. Abstract at the Association for Laboratory Automation Labautomation'97 Conference, 1997 Jan. 18-22, San Diego. On the World Wide Web URL http://labautomation.org.
Czarnik and Nova (1997), "No static at all." Chemistry in Britain, Oct., pp. 39-41.
Daniels et al. (1990, "Membranes as novel solid supports for peptide synthesis," Peptides, Proceedings of the Eleventh American Peptide Symposium Jul. 9-14, 1998 (Rivier and Marshall, eds.), pp. 1027-1028.
DeWitt et al. (1996), "Combinatorial Organic Synthesis Using Park-Davis Diversomer Method," Acc. Chem. Res. 29:114-122.
DeWitt et al. (1994), "Diversomer Technology: solid phase synthesis, automation, and integration for the generation of chemical diversity," Drug Dev. Res. 33:116-124.
DeWitt et al. (1996), "A modular System for combinatorial and Automated Synthesis" in Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery. ACS Conference Proceedings Series (Chaiken and Janda Eds.) pp. 207-218. American Chemical Society, Washington DC.
DeWitt et al. (1995), "Automated synthesis and combinatorial chemistry," current Opinion in Biotechnology 6:640-645.
DeWitt et al. (1993), "Diversomers": An approach to nonpeptide, nonoligomeric chemical diversity. Proc. Natl. Acad. Sci. U.S.A. 90:6909-6913.
Floyd et al. (1997), "The Automated Synthesis of Organic Compunds--some Newcomers have Some Success" in "Proceedings of the International Symposium on Laboratory Automation and Robotics 1996" pp. 51-76. Zymark Corporation, Zymark Center, Hopkinton, MA.
Frank (1994), "Spot-synthesis: An easy and flexible tool to study molecular recognition," Innovation and Perspectives in Solid Phase Synthesis, (Epton, ed.), pp. 509-512.
Frank et al. (1988), "Simultaneous multiple peptide synthesis under continuous folw conditions on cellulose paper discs as segmental solid supports," Tetrahedron 44:6031-6040.
Furka et al. (1991), "General method for rapid synthesis of multicomponent peptide mixtures," Int. J. Pept. Protein Res. 37:487-493.
Gooding et al. (1996), "Boosting the Productivity of Medicinal Chemistry Through Automation Tools, Novel Technological Developments Enable a Wide Range of Automated Synthetic Procedures" in "Molecular Diversity and Combinatorial chemistry: Libraries and Drug Discovery. ACS Conference Proceedings Series"(Chaiken et al.) pp. 199-206. American Chemical Society, Washington, DC.
Harness (1996), "Automation of High-Throughput Synthesis. Automated Laboratory Workstations Designed to Perform and Support Combinatorial Chemistry" in "Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery. ACS Conference Proceedings Series" (Chaiken et al.) pp. 188-198. American Chemical Society, Washington, DC.
Kerr et al. (1993), "Encoded combinatorial peptide libraries containing non-natural amino acids," J. Am. Chem. Soc. 115:2529-2531.
Lam et al. (1991), "A new type of synthetic peptide library for identifying ligand-binding activity," Nature (London), 354:82-84.
Lashkari et al. (1995), "An automated multiplex oligonucleotide synthesizer: Development of high-throughput, low-cost DNA synthesis," Proc. Natl. Acad. Sci. USA 92:7912-7915.
Lebl et al. (1995), "One-bead-one-structure combinatorial libraries," Biopolymers, 37:177-198.
Meyers et al., "Multiple simultaneous synthesis of phenolic libraries," ESCOM Science Publishers B

Affiliated with

Also associated with

Rating

Methods for parallel synthesis of organic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for parallel synthesis of organic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for parallel synthesis of organic compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2335594