Methods for optimizing fluoropyrimidine cancer therapy

Details Methods for optimizing fluoropyrimidine cancer therapy Methods for optimizing fluoropyrimidine cancer therapy

1995-06-22

1997-09-23

Richter, Johann

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

C12Q 148

Patent

active

056703317

ABSTRACT:
The present invention provides a method of predicting whether an individual will be intolerant to the effect of fluoropyrimidines comprising the step of measuring the activity of orotate phosphoribosyltransferase activity in a biological sample obtained from said individual. Also provided is a method of determining a non-toxic dose of 5-fluoruracil in an individual in need of fluoropyrimidine therapy, comprising the step of measuring the activity of 5-fluoruracil phosphoribosyltransferase (FUPRTase) in a biological sample obtained from said individual.

REFERENCES:
Traut et al., Biochem. Pharm., 26, 2291-96 (1977).
Tampitag et al., Mol. Biochem. Parasitology, 18 , 125-34 (1986).
Peters et al., Cancer Res., 46, 20-28, 1986.
Peters et al., Br. J. Cancer, 59, 327-34 (1989).

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