Methods for one-pot N -demethylation/ N -acylation of...

Details Methods for one-pot N -demethylation/ N -acylation of... Methods for one-pot N -demethylation/ N -acylation of...

2011-08-16

2011-08-16

Aulakh, Charanjit (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S044000

Reexamination Certificate

active

07999104

ABSTRACT:
The present invention provides a method for the N-demethylation and/or N-acylation of an N-methylated heterocycle such as morphine alkaloids or tropane alkaloids. The method comprises reacting the heterocycle with an acylating agent in the presence of a metal catalyst.

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Ripper, J.A. et al.: Photochemical N-demethylation of alkaloids. Bioorg. & Mrd. Chem. Lett., vol. 11, pp. 443-445, 2001.

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