Methods for obtaining production of a gene product in a host cel

Details Methods for obtaining production of a gene product in a host cel Methods for obtaining production of a gene product in a host cel

1995-06-07

1998-04-28

Rories, Charles C. P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 6, 435 691, 435 701, 435 703, 435 704, 435 9141, 4351723, 435325, 435355, 435372, 4353723, 536 241, A61K 4800, C12N 1567, C12N 1585, C12N 510

Patent

active

057444560

ABSTRACT:
Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant activator sequence capable of eliciting host cell-type restricted, integration site independent, copy number dependent expression of the gene.

REFERENCES:
S. McCune et al., Nucleic Acids Res., 22(21) ('94) 4477-81.
J. Chang et al., PNAS 89 (Apr. 1992) 3107-10.
R. Mulligan, Science, 260 (May 14, 1992) 926-32.
A. Miller, Blood, 76(2) (Jul. 15, 1990) 271-8.
A. Miller, Nature 357 (Jun. 11, 1992) 455-60.
T. Friedmann Science 244 (Jun. 16, 1989) 1275-1281.
M. Kay et al., TIG 10(7) (Jul. 1994) 253-7.

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