Methods for obtaining paclitaxel from taxus plants

Details Methods for obtaining paclitaxel from taxus plants Methods for obtaining paclitaxel from taxus plants

2006-09-26

2006-09-26

McKenzie, Thomas (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S511000

Reexamination Certificate

active

07112687

ABSTRACT:
Methods for obtaining paclitaxel from plants containing paclitaxel are disclosed. Plant material is first obtained from plants containing paclitaxel. Paclitaxel is then extracted from the plant material. Subsequently, paclitaxel is separated from the paclitaxel extract using a series of column chromatography separation steps to obtain at least one fraction containing paclitaxel. The paclitaxel in a fraction that is obtained from the final chromatography step is crystallized. Using these methods, high purity paclitaxel may be efficiently obtained from plants containing paclitaxel.

REFERENCES:
patent: 5475120 (1995-12-01), Rao
patent: 6333419 (2001-12-01), Gabetta et al.

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