Chemistry: analytical and immunological testing – Involving diffusion or migration of antigen or antibody – Through a gel
Patent
1987-02-19
1988-12-20
Moskowitz, Margaret M.
Chemistry: analytical and immunological testing
Involving diffusion or migration of antigen or antibody
Through a gel
435 7, 435 68, 436510, 436516, 436518, 436536, 436548, 935108, 935110, 530387, G01N 33537, G01N 33561, G01N 33577
Patent
active
047925280
ABSTRACT:
Mixtures of monoclonal antibodies which contain effective assaying amounts of each of at least two monoclonal antibodies that bind to different antigenic sites on the antigen and are capable under appropriate conditions of binding simultaneously to an antigen are useful in enhanced sensitivity assays for the antigen. By utilizing such mixtures in diagnostic assays for important antigens such as the polypeptide human chorionic gonadotropin enhanced sensitivity can be achieved as compared with assays employing individual monoclonal antibodies.
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Canfield Robert E.
Ehrlich Paul H.
Moyle William R.
Moskowitz Margaret M.
The Trustees of Columbia University in the City of New York
White John P.
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