Methods for neutron-capture tumor therapy

Details Methods for neutron-capture tumor therapy Methods for neutron-capture tumor therapy

1982-06-22

1985-05-14

Howell, Kyle L.

Surgery

Truss

Perineal

2505181, A61N 512

Patent

active

045165351

ABSTRACT:
A tumorous patient is injected with a compound including an element that accumulates in tumors and that has an isotope which emits an alpha particle in a neutron capture reaction. The patient is positioned in front of a radiation beam that has been filtered to remove most neutrons having energies above 30 KeV and most thermal neutrons, leaving predominantly epithermal neutrons which are moderated to a thermal level by outer layers of tissue and are captured by the incorporated isotope.
A radiation beam having neutrons with a wide distribution of energies is filtered with aluminum and sulfur filters, whose cross sections complement each other in providing a beam with energies predominantly in the epithermal range. The filter mass attenuates the gamma radiation. Beams with lower ratios of undesirable gamma radiation to epithermal beam intensity can be attained with filter combinations which include liquid argon. A poor geometry filter of bismuth or lead can also improve the gamma to neutron ratio. Preferably the beam is filtered through a thermal neutron filter as well.

REFERENCES:
Fairchild, R. G., "Development and Dosimetry of an `Epithermal` Neutron Beam for Possible Use in Neutron Capture Therapy I. `Epithermal` Neutron Beam Development", Phys. Med. Biol., vol. 10, No. 4, pp. 491-504, (1965).
Zamahof, R. G. et al., "Boron Neutron Capture Therapy for the Treatment of Cerebral Gliomas I: Theoretical Evaluation of the Efficacy of Various Neutron Beams", Medical Physics, vol. 2, No. 2, Mar./Apr. 1975, pp. 47-60.
McDonald, J. et al., "Clinical Oncology for Medical Students and Physicians", Univ. of Rochester School of Med. and Dent., 1974, pp. 343-358.
Acta Radiologia, (Supplement 170), pp. 50-53, 1958.
Hatanaka et al., "Boron-Neutron Capture Therapy in Relation to Immunotherapy", Acta Neurochirurgica 42, pp. 55-72, (1978).
Hatanaka et al., "A Revised Boron-Neutron Capture Therapy for Malignant Brain Tumours", Z. Neurol. 204, pp. 309-332.
Brownell et al., "Boron Neutron Capture Therapy", (1978), pp. 205-222, In: Modern Trends in Radiotherapy I, Deley & Wood (eds), Butterworths, London.

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