Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-11-10
1997-07-01
Guzo, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
935 36, C12Q 168, C12N 1563
Patent
active
056437269
ABSTRACT:
The application concerns methods for modulating transcription from the amyloid .beta.-protein precursor (APP) promoter. The upstream stimulatory factor (USF) is described as being capable of activating transcription from the APP promoter. Also described are USF binding compounds which are capable of down-regulating expression from the APP promoter. Preferred USF binding compounds are the amyloid precursor-like proteins APLP1 and APLP2. The application further concerns a screening assay for determining which candidate USF binding compounds are capable of causing down-regulation of transcription from the APP promoter.
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International Search Report from International Appl. No. PCT/US95/14416; date of mailing: Feb. 28, 1996.
Kovacs Dora M.
Tanzi Rudolph E.
Guzo David
Schwartzman Robert
The General Hospital Corporation
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