Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-06-07
2000-11-07
Hauda, Karen M.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
435375, 4353201, 4351723, A61K 4800, C12N 510, C12N 1509
Patent
active
061432911
ABSTRACT:
Methods for protecting a T cell from cell death are described. The methods involve contacting the T cell with an agent which augments the bcl-X.sub.L protein level in the T cell such that it is protected from cell death. The invention further pertains to methods for increasing the susceptibility of a T cell to cell death, comprising contacting the T cell with at least one agent which decreases bcl-X.sub.L protein level in the T cell. Both in vivo and in vitro methods are described.
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June Carl H.
Thompson Craig B.
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