Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-04-15
2008-04-15
Robinson, Hope (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C530S350000
Reexamination Certificate
active
07358056
ABSTRACT:
Methods are provided for identifying agents that modulate signaling mediated by transforming growth factor beta (TGF-β) and members of the TGF-β family, such as bone morphogenic protein (BMP). Such agents may be identified using screens that evaluate candidate agents for the ability to modulate Smad protein degradation. Agents identified as described herein may be used to augment or inhibit signaling mediated by one or more TGF-β family members in a variety of cell types and for therapeutic purposes.
REFERENCES:
patent: 6001619 (1999-12-01), Beach et al.
patent: 6011137 (2000-01-01), Pirozzi et al.
patent: 6060262 (2000-05-01), Beer-Romero et al.
patent: 6087122 (2000-07-01), Husted et al.
patent: 6103869 (2000-08-01), Souchelnytokyi et al.
patent: WO 99/01765 (1999-01-01), None
patent: WO 00/77168 (2000-12-01), None
Zhu et al., A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic differentiation. 1999, Nature vol. 400, pp. 687-693.
Guo et al., PNAS, vol. 101, No. 25, pp. 9205-9210, 2004.
Wells, Biochemistry, vol. 29, pp. 8509-8517, 1990.
Attisano et al., 1993, “Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors”, Cell 75(4):671-80.
Attisano et al., 1996, “Activation of signalling by the activin receptor complex”, Mol Cell Biol. 16(3):1066-73.
Cui et al., 1996, “TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice”, Cell 86(4):531-42.
Derynck, 1998, “Smads: transcriptional activators of TGF-beta responses”, Cell 95(6):737-40. R.
Hayashi et al., 1997, “The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling”, Cell 89(7):1165-73.
Heldin et al., 1997, “TGF-beta signalling from cell membrane to nucleus through SMAD proteins”, Nature 390: 465-471.
Hershko et al., 1983, “Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown”, J Biol Chem. 258(13):8206-14.
Hojo et al., 1999, “Cyclosporine induces cancer progression by a cell-autonomous mechanism”, Nature 397(6719):530-4.
Huibregtse et al., 1995, A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci U S A. 92(7):2563-7.
Huibregtse et al., 1993, “Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53”, Mol Cell Biol. 13(2):775-84.
Imamura, 1997, “Smad6 inhibits signalling by the TGF-beta superfamily”, Nature 389(6651):622-6.
Kretzschmar et al., 1997, “Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1”, Nature 389(6651):618-22.
Kretzschmar and Massague, 1998, “SMADs: mediators and regulators of TGF-beta signaling”, Curr Opin Genet Dev. 8(1):103-11.
Lin et al., 1992, “Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase”, Cell 68(4):775-85.
Liu et al., 1996, “A human Mad protein acting as a BMP-regulated transcriptional activator”, Nature 381(6583):620-3.
Markowitz et al., 1995, “Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability”, Science 268(5215):1336-8.
Mathews and Vale, 1991, “Expression cloning of an activin receptor, a predicted transmembrane serine kinase”, Cell. 65(6):973-82.
Miyazono et al., 1999, “Signal transduction by bone morphogenetic protein receptors”, Bone 25(1): 91-93.
Nakao et al., 1997, “Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway”, J Biol Chem. 272(5):2896-900.
Newfeld et al., 1996, “Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells”, Development 122(7):2099-108.
Pirozzi et al., 1997, “Identification of novel human WW domain-containing proteins by cloning of ligand targets”, J Biol Chem. 272(23):14611-6.
Reynisdottir et al., 1995, Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev. 9(15):1831-45.
Sekelsky et al., 1995, “Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function inDrosophilamelanogaster”, Genetics 139(3):1347-58.
Staub et al., 1996, “WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome”, EMBO J. 15(10):2371-80.
Sudol et al., 1996, “Structure and function of the WW domain”, Prog Biophys Mol Biol. 5(1-2):113-32.
Tsuchida et al., 1993, “Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor”, Proc Natl Acad Sci U S A. 90(23):11242-6.
Ulloa et al., 1999, Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 397(6721):710-3.
Zawel et al., 1998, “Human Smad3 and Smad4 are sequence-specific transcription activators”, Mol Cell. 1(4):611-7.
Zhang et al., 1996, “Receptor-associated Mad homologues synergize as effectors of the TGF-beta response”, Nature 383(6596):168-72.
Zhu et al., 1998, “Smad3 mutant mice develop metastatic colorectal cancer”, Cell 94(6):703-14.
Zhu et al., 1999, “A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation”, Nature 400: 687-93.
Wrana et al., 2000, “The Smad pathway,” Cytokine & Growth Factor Reviews 11:5-13.
Hoekstra Merl F.
Mercurio Frank M.
Murray Brion W.
Xie Weilin
Jones Day
Robinson Hope
Signal Pharmaceuticals
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