Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1984-03-14
1988-02-23
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435184, 435188, 435810, 436512, 436537, 436808, 436501, G01N 33535, G01N 33542, G01N 33563, C12N 996, C12N 999
Patent
active
047270225
ABSTRACT:
Methods are provided for modulating Ligand-Receptor interactions by binding of molecules at two epitopes of a receptor, where the epitopes are in relatively close special relationship. By providing for inhibition of changes in conformation of the receptor, where the inhibition is due to steric interactions or molecular bridging between the two epitopic sites, Ligand-Receptor interactions may be modulated. The modulation of Ligand-Receptor interactions has application to diagnostic assays, modulation of cellular activity, and modulation of the physiological activity of macromolecular compounds.
REFERENCES:
patent: 3879262 (1975-04-01), Schuurs et al.
patent: 4130462 (1978-12-01), Rubenstein et al.
patent: 4134792 (1979-01-01), Boguslaski et al.
patent: 4208479 (1980-06-01), Zuk et al.
Gould Dennis R.
Skold Carl
Ullman Edwin F.
Kepplinger Esther M.
Leitereg Theodore J.
Rowland Bertram A.
Syntex (U.S.A.) Inc.
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