Methods for modifying the binding activity of cell adhesion rece

Details Methods for modifying the binding activity of cell adhesion rece Methods for modifying the binding activity of cell adhesion rece

1993-08-09

1998-06-02

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

424600, 424678, 424681, 435334, 514492, C12N 506, A01N 5906, A61K 3306

Patent

active

057598550

ABSTRACT:
The invention relates to the regultory role of cations on the dynamics of integrin-mediated cell adhesion and migration. In one aspect, methods of promoting or inhibiting the migration of integrin-expressing cells are provided by controlling the amount of cations, such as Mg.sup.2+ or Ca.sup.2+, in contact with the integrins of the cells. Methods of modifying the binding avidity of an integrin for its ligand are also provided by regulating the concentration of cations in contact with the integrin. The invention further relates to methods of using cations for a variety of applications and in particular for promoting wound healing.

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