Methods for modifying cell contact with a surface

Details Methods for modifying cell contact with a surface Methods for modifying cell contact with a surface

1995-06-06

1996-10-22

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424485, 424486, 424488, A61K 914

Patent

active

055674402

ABSTRACT:
Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.

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patent: 4434150 (1984-02-01), Azad et al.
patent: 4663268 (1987-05-01), Tsang et al.
patent: 4808355 (1989-02-01), Goosen et al.
patent: 4923645 (1990-05-01), Tsang et al.

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