Methods for modelling tertiary structures of biologically active

Chemistry: analytical and immunological testing – Nuclear magnetic resonance – electron spin resonance or other...

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324307, 324312, 436 86, 436172, 530315, 530316, G01N 2408

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active

054590779

ABSTRACT:
Disclosed are methods for modelling the three-dimensional structure (tertiary structure) of a ligand having one or more active sites employing a charge-transfer interaction. Also disclosed is a model for Angiotensin II derived from such method.

REFERENCES:
patent: 3751404 (1973-08-01), Sipos et al.
patent: 4355040 (1982-10-01), Furukawa et al.
patent: 4386026 (1983-05-01), Ponpipom et al.
patent: 4485177 (1984-11-01), Siedel et al.
patent: 4578361 (1986-03-01), Siedel et al.
patent: 4702864 (1987-10-01), Maegolda et al.
patent: 4772684 (1988-09-01), Brunck et al.
patent: 4789832 (1988-12-01), Nagayama
patent: 4818684 (1989-04-01), Edelman et al.
patent: 4822746 (1989-04-01), Walt
patent: 4830961 (1989-05-01), Petty
patent: 4845075 (1989-07-01), Murray et al.
patent: 4849407 (1989-07-01), Murray et al.
patent: 4853871 (1989-08-01), Pantoliano et al.
patent: 5015651 (1991-05-01), Carini et al.
patent: 5043349 (1991-08-01), Carini et al.
Chem, Abstr. 1974, 81, Abstract No. 81:46793m.
Chem. Abstr. 1976, 85, Abstract No. 85:160476t.
Chem. Abstr. 1978, 88, Abstract No. 88:148329b.
Chem. Abstr. 1982, 96, Abstract No. 96:123275h.
Chem. Abstr. 1987, 107, Abstract No. 107:90191t.
Otter et al. "Solution Conformation of N-Acetyl-L-prolyl-glutaminyl-L-prolyl-L-prolyl-L-glutaminamide, a Pentapeptide Fragment of the Type I Collagen .alpha.-1 Chain C-Telopeptide, Determined by Phase-Sensitive Two Dimensional NMR Techniques" J. Am. Chem. Soc. 1987, 109, 6995-7001.
Steve Cheatham "Nuclear Magnetic Resonance Spectroscopy in Biochemistry" J. Chem. Ed. 1989, 66, 111-117.
Surewicz et al. "Conformational Properties of Angiotensis II in Aqueous Solution and in a Lipid Environment: A Fouvier Transform Infrared Spectroscopic Investigation" J. Am. Chem. Soc. 1988, 4412-4414.
Deranleau, D. A. J. Am. Chem. Soc. 1975, 97, 1218-1224.
Wombacher, H. et al. Z. Naturforsh. 1976, 31, 18-20.
Grinvald, A. et al. Biochim. Biophys. Acta 1976, 427, 663-678.
Mayer, R. et al. J. Bio. Chem. 1979, 254, 75-82.
Lown, J. W. et al. J. Am. Chem. Soc. 1982, 104, 3214-3216.
Tran, C. D. et al. J. Am. Chem. Soc. 1982, 104, 3002-3007.
Kanellis, P. et al. Arch. Biochem. Biophys. 1983, 220, 530-540.
Marion, D. et al. Biochem. Biophys. Res. Commun. 1983, 113, 967-974.
J. D. Glickson et al. Pept. Proc. Am. Pept. Symp., 5th 1977, 325-328.
J. P. Demonte et al. Int. J. Pept. Protein Res. 1981, 18, 478-486.
H. Tanaka et al. Pept. Chem. 1985 (Pub. 1986) 24rd, 311-316.
W. R. Laws et al. Biochemistry 1986, 25, 599-607.
C. O. Pabo et al. Biochemistry 1986, 25, 5987-5991.
M. C. Fournie-Zaluski et al. Pept. Proc. Eur. Pepti Symp, 19th 1986, 345-348.
G. Bovermann et al. Pept. Proc. Eur. Pept. Symp. 19th, 1986, 311-314.
G. V. Nikiforovich et al, J. Biomol. Struct. Dyn. 1987, 4, 1119-1135.
R. T. Gampe et al. Biopolymers 1988, 27, 313-321.
R. T. Science 1992, 256, 441.
J. S. Dixon Trends Biochem. 1992, 10, 357-363.
Moore, et al, "Angiotensin as a model for hormone--receptor interactions", Bioscience Reports, vol. 5 (1985), pp. 407-416.
Moore, et al, "Structure-desensitization relationships of angiotensin analogues in the rat isolated uterus", Can. J. Physiol. Pharmacol., vol. 63 (1985), pp. 966-991.
Matsoukas, et al, "Proton Magnetic Resonance Studies of Angiotensin II Conformation: cis-trans Isomerism in Sarcosine.sup.7 -Containing Analogs", Archives of Biochemistry and Biophysics, vol. 248, No. 1 (1986), pp. 419-423.
Rauk, et al, "Mechanistic Consequences of Charge Transfer Systems in Serine Proteases and Angiotensin: Semiempirical Computations", Biochemical and Biophysical Research Communications, vol. 145, No. 3 (1987), pp. 1349-1355.
Matsoukas, et al, "NMR and Mass Spectroscopic Studies of the Competitive Angiotensin II Antagonist `Sarmesin`", Spectroscopy Letters, vol. 21, No. 5 (1988), pp. 477-491.
Moore, et al, "Methods for Analyzing and Interpreting Cooperativity in Dose-Response Curves-I. Antagonist Effects on Agiotensin Receptors in Smooth Muscle", General Pharmacology, vol. 20, No. 2 (1989), pp. 193-198.
Moore, et al, "Angiotensin `Antipeptides`: (-)Messenger RNA Complementary to Human Angiotensin II (+)Messenger RNA Encodes an Angiotensin Receptor Antagonist", Biochemical and Biophysical Research Communications, vol. 160, No. 3 (1989), pp. 1387-1391.
Fisher, et al., Biochemistry, "1H NMR Studies of Bovine and Porcine Phospholipase A2: Assignment of Aromatic Resonances and Evidence for a Conformational Equilibrium in Solution", 28(11):5939-5946 (1989).
Moore, et al., Biochemistry, ".sup.1 H NMR Studies of Plastocyanin from Scenedesmus obliquus: Complete Sequence-Specific Assignment, Secondary Analysis, and Global Fold", 27:7806-7816 (1988).
Ostrovskii, et al., Soviet Journal of Quantum Electronics, "Investigation of the Dynamics of the Structure of Biopolymers by the Method of Kinetic Spectrofluorometry", 16:772-775 (1986).
Kaiser, et al, Science, "Amphiphilic Secondary Structure: Design of Peptide Hormones" 223:249-255 (1984).
Chemical Abstracts, vol. 100, No. 23, 4 Jun. 1984, Abstract No. 192245m.
Chemical Abstracts, vol. 104, No. 21, 26 May 1986, Abstract No. 182239f.
Chemical Abstracts, vol. 97, No. 1, 5 Jul. 1982, Abstract No. 2458g.
Chemical Abstracts, vol. 102, No. 23, 10 Jun. 1985, Abstract No. 204280a.
Moore, International Journal of Peptide and Protein Research, "Kinetices of Acetylation-Deacetylation of Angiotensin II", 26(5):469-481 (1985).
Matsoukas, et al., J. Med. Chem., "Importance of the N-terminal Domain of the Type II Aniotensin Antagonist Sarmesin for Receptor Blockade", 31(7):1418-1421 (1988).
Duncia, et al., J. Med. Chem., "The discovery of Potent Non-Peptide Angiotensin II Receptor Antagonists: A New Class of Potent Antihypertensives", 33(5):1312-1329 (1990).
Carini, et al., J. Med. Chem., "Nonpeptide Angiotensin II Receptor Antagonists: N-[(Benzyloxy)benzyl]imida-zoles and Related Compounds as Potent Antihyper-tensives", 33:1330-1336 (1990).
Chary, et al., "Molecular Conformation of Gonadoliberin Using Two-Dimensional NMR Spectroscopy", Eur. J. Biochem., 158:323-322 (1986).
Skoog and West, "Principles of Instrumental Analysis", 2nd Edition, pp. 280-297.
Goghari, et al, "Structure-Activity Relationships for the Competitive Angiotensin Antagonist [Saricosine.sup.1, O-methyltyrosine.sup.4 ] angiotensin II (Sarmesin)", Journal of Medicinal Chemistry, vol. 29, No. 6 (1986), pp. 1121-1124.
Matsoukas, et al, "Synthesis and Biological Activities of Analogues of Angiotensin II and III Containing O-Methyltyrosine and D-Tryptophan", Journal of Medicinal Chemistry, vol. 28, No. 6 (1985), pp. 780-783.
Wong, et al, "Nonpeptide Angiotensin II Receptor Antagonists. IV. EXP6155 and EXP6803", Hypertension, vol. 13, No. 5 (May 1989), pp. 489-497.
Kessler, et al, "Separation of Cross-Relaxation and J Cross-Peaks in 2D Rotating-Frame NMR Spectroscopy", Journal of American Chemical Society, vol. 109, No. 2 (1987), pp. 607-609.
Moore, et al, "Synthesis of Angiotensin II Antagonists Containing Sarcosine in Position 7", Journal of Medicinal Chemistry, vol. 22, No. 9 (1979), pp. 1147-1149.
Scanlon, et al, "A New Approach to Angiotensin Antagonists: Methylation of the Tyrosine Hydroxyl in Angiotensin II", Life Sciences, vol. 34, No. 4 (1984), pp. 317-321.
Higashijima, T. et al, Eur. J. Biochem. 1984, 140, 163-171.
Ross, J. B. A. et al. Biochemistry, 1986, 25, 607-612.
Devaux, P. F. et al. Biochem. Biophys. Acta 1985, 822, 63-125.
Hass, E. et al. Biochemistry, 1987, 26, 1672-1683.
Weaver, A. J. et al. Biochemistry, 1989, 28, 8614-8623.
Weaver, A. J. et al. Biochemistry 1989, 28, 8624-8639.
Chemical Abstracts 1987, 107, Abstract No. 107:147522h.
Chem. Abstr. 1987, 107, Abstract No. 107:147524k.

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