Bleaching and dyeing; fluid treatment and chemical modification – Treatment of hides – skins – feathers and animal tissues – Internal tissues
Patent
1996-07-30
1998-07-21
Diamond, Alan
Bleaching and dyeing; fluid treatment and chemical modification
Treatment of hides, skins, feathers and animal tissues
Internal tissues
623 1, 623 2, 623 11, 623 12, 623 13, 623 14, 623 15, A61L 2700
Patent
active
057829314
ABSTRACT:
Methods for treating glutaraldehyde-fixed collagenous tissues to mitigate their propensity for subsequent calcification and to improve durability. Collagenous tissues which have been harvested and cross-linked by glutaraldehyde are exposed to a carboxyl activating agent to convert the free carboxyl (COOH) groups of the collagen molecules to activated carboxyl moieties (e.g., o-acylisourea). Thereafter, the collagenous tissue is exposed to a compound capable of reacting with the activated carboxyl moieties (e.g., o-acylisourea) to form non-carboxyl side groups. Monofunctional and multi-functional amines are examples of compounds which may be utilized to react with the activated carboxyl moieties to form such non-carboxyl side groups. Thereafter, the collagenous tissue is again exposed to glutaraldehyde. If the non-carboxyl side groups have functional amino groups (NH.sub.2), such additional exposure to glutaraldehyde will result in additional glutaraldehyde cross-linking of the collagen molecules and resultant improvement of durability.
REFERENCES:
patent: 3954583 (1976-05-01), Lednicer et al.
patent: 3975371 (1976-08-01), Lednicer et al.
patent: 4008208 (1977-02-01), Lednicer et al.
patent: 4120649 (1978-10-01), Schechter
patent: 4134867 (1979-01-01), Topfl
patent: 4245358 (1981-01-01), Moasser
patent: 4323358 (1982-04-01), Lentz et al.
patent: 4378224 (1983-03-01), Nimni et al.
patent: 4396716 (1983-08-01), Marconi et al.
patent: 4402697 (1983-09-01), Pollock et al.
patent: 4405327 (1983-09-01), Pollock
patent: 4549545 (1985-10-01), Levy
patent: 4553974 (1985-11-01), Dewanjee
patent: 4648881 (1987-03-01), Carpentier et al.
patent: 4753652 (1988-06-01), Langer et al.
patent: 4759758 (1988-07-01), Gabbay et al.
patent: 4772288 (1988-09-01), Borner et al.
patent: 4830847 (1989-05-01), Benedict et al.
patent: 4831065 (1989-05-01), Pietsch et al.
patent: 4838888 (1989-06-01), Nashef
patent: 4885005 (1989-12-01), Nashef et al.
patent: 4958008 (1990-09-01), Petite et al.
patent: 4976733 (1990-12-01), Giradot
patent: 4994237 (1991-02-01), Login et al.
patent: 4996054 (1991-02-01), Pietsch et al.
patent: 5002566 (1991-03-01), Carpentier et al.
patent: 5011913 (1991-04-01), Benedict
patent: 5051401 (1991-09-01), Sikes
patent: 5080670 (1992-01-01), Imamura et al.
patent: 5094661 (1992-03-01), Levy et al.
patent: 5104405 (1992-04-01), Nimni
patent: 5147514 (1992-09-01), Mechanic
patent: 5165919 (1992-11-01), Sasaki et al.
patent: 5296583 (1994-03-01), Levy
patent: 5314874 (1994-05-01), Miyata et al.
patent: 5326370 (1994-07-01), Love et al.
patent: 5332475 (1994-07-01), Mechanic
patent: 5336616 (1994-08-01), Livesey et al.
patent: 5368608 (1994-11-01), Levy et al.
patent: 5423887 (1995-06-01), Love et al.
patent: 5436291 (1995-07-01), Levy et al.
patent: 5437287 (1995-08-01), Phillips et al.
patent: 5447536 (1995-09-01), Giradot et al.
patent: 5476516 (1995-12-01), Seifter et al.
Bernacca, Gillian M., et al, J. Heart Valve Dis., vol. 1, No. 1, Sep. 1992, "In Vitro Calcification of Bioprosthetic Heart Valves: Report of Novel Method and Review of the Biochemical Factors Involved." pp. 115-130.
Bernacca, G.M., et al, Biomaterials, 1992, vol. 13, No. 6, "Chemical Modification of Bovine Pericardium and Its Effect on Calcification in the Rat Subdermal Model," (Month Unknown).
Yi, D., et al, Proceedings of Chinese Tissue Valve Conference, Beijing, China 1995, "Study of Calcification Mechanism and Anticalcification On Cardiac Bioprostheses," pp. 17-22 (Abstract). (Month Unknown).
Tingfei, Xi, et al, Journal of Biomedical Materials Research, vol. 26, 1992, "Prevention of Tissue Calcification on Bioprosthetic Heart Valve by Using Epoxy Compounds: A Study of Calcification Tests In Vitro and In Vivo," pp. 1241-1251 (Month Unknown).
Shen Shih-Hwa
Yang Jun
Baxter International Inc.
Buyan Robert D.
Condino Debra D.
Cumberbatch Guy L.
Diamond Alan
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