Methods for microbial production of terpenoids

Details Methods for microbial production of terpenoids Methods for microbial production of terpenoids

2009-11-10

2011-11-22

Noakes, Suzanne M (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

C435S252300, C435S041000

Reexamination Certificate

active

08062878

ABSTRACT:
The invention relates to recombinant expression of terpenoid synthase enzymes and geranylgeranyl diphosphate synthase (GGPPS) enzymes in cells and the production of diterpenoids.

REFERENCES:
patent: 2002/0164736 (2002-11-01), Matsuda et al.
patent: 2007/0009996 (2007-01-01), Matsuda et al.
Ajikumar et al., Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms. Mol Pharm. Mar.-Apr. 2008;5(2):167-90. Epub Mar. 21, 2008.
Huang et al., EngineeringEscherichia colifor the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol. Bioorg Med Chem. Sep. 2001;9(9):2237-42.
Kirby et al., Biosynthesis of plant isoprenoids: perspectives for microbial engineering. Annu Rev Plant Biol. 2009;60:335-55.
Leonard et al., Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control. Proc Natl Acad Sci U S A. Aug. 3, 2010;107(31):13654-9. Epub Jul. 19, 2010.
Reiling et al., Mono and diterpene production inEscherichia coli. Biotechnol Bioeng. Jul. 2004;87(2):200-12.
Wang et al., Directed evolution of metabolically engineeredEscherichia colifor carotenoid production. Biotechnol Prog. Nov.-Dec. 2000;16(6):922-6.

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