Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2003-04-17
2010-06-01
Low, Christopher (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C506S006000, C506S011000, C506S018000
Reexamination Certificate
active
07727739
ABSTRACT:
The invention relates to fluorescence methods for measuring enzyme activity, in particular enzyme cleaving and joining activities. The invention also relates to fluorogenic substrates which are useful for measuring enzyme activity and as in vitro and in vivo imaging probes.
REFERENCES:
patent: 4598043 (1986-07-01), Svendsen
patent: 5108908 (1992-04-01), Coves et al.
patent: 5708137 (1998-01-01), Toth et al.
patent: 5807746 (1998-09-01), Lin et al.
patent: 5968479 (1999-10-01), Ito et al.
patent: 6133445 (2000-10-01), Waggoner et al.
patent: 6251583 (2001-06-01), Zhang et al.
patent: 6323186 (2001-11-01), Klaubert et al.
patent: 6410255 (2002-06-01), Pollok et al.
patent: 6447724 (2002-09-01), Jensen et al.
patent: 2001/0004522 (2001-06-01), Burke et al.
patent: 2001/0005752 (2001-06-01), Auer et al.
patent: 2005/0176926 (2005-08-01), Marme
patent: 0 004 256 (1982-07-01), None
patent: 0 428 000 (1990-10-01), None
patent: 0 231 125 (1992-08-01), None
patent: WO79/00602 (1979-08-01), None
patent: WO 91/16336 (1991-10-01), None
patent: WO 94/28166 (1994-12-01), None
patent: WO 95/25093 (1995-09-01), None
patent: WO 98/29562 (1998-07-01), None
patent: WO 98/47538 (1998-10-01), None
patent: WO 99/05302 (1999-02-01), None
patent: WO00/73437 (2000-12-01), None
patent: WO 01/41811 (2001-06-01), None
patent: WO 02/056670 (2002-07-01), None
patent: WO 02/081509 (2002-10-01), None
patent: WO 02/099424 (2002-12-01), None
patent: WO 02/099432 (2002-12-01), None
Karp et al. Time-resloved Europium Fluorescence in Enzyme Activity Measurements: A Sensitive Protease Assay.1983 J. Applied Biochemistry 5:399-403.
Fawell et al. Tat-mediated delivery of heterologous proteins into cells. 1994 PNAS 91:664-668.
Larcchia-Robbio et al. Detection and epitope mapping of immunoreactive human endothelin-1 using ELISA and a surface plasmon resonance-bases biosensor. 1997 Biosensors & Bioelectronics 12:765-778.
Reymond et al. A general assay for antibody catalysis using acridone as a fluroescent tag. 1996 PNAS 93: 4251-4256.
Szollosi et al. Application of fluroescence resonance energy transfer in the clinical laboratory: routine and research. 1998 Cytometry 34:159-179.
Deshayes et al 2005 Cell Mol. Life Sci. 62:1839-1849.
Faller, T., et al., “A novel acridone derivative for the fluorescence tagging and mass spectrometric sequencing of peptides”,Chem. Commun., 1997, p. 1529-1530.
Meldal, M., et al., “Anthranilamide and Nitrotyrosine as a Donor-Acceptor Pair in Internally Quenched Fluorescent Substrates for Endopeptidases: Multicolumn Peptide Synthesis of Enzyme Substrates for Subtilisin Carlsberg and Pepsin”,Analytical Biochemistry, vol. 195, 1991, p. 141-147.
Bahr, N., et al., “Highly Photoresistant Chemosensors using Acridone as Fluorescent Label”,Tetrahedron Letters, vol. 38, No. 9, 1997, p. 1489-1492.
Wang, W., et al., “Fluorogenic Peptides Containing Only α-Amino Acids”,Biochemical and Biophysical Research Communications, vol. 201, No. 2, 1994, p. 835-840.
Hawiger, J., “Noninvasive Intracellular Delivery of Functional Peptides and Proteins”,Current Opinion in Chemical Biology, vol. 3, 1999, p. 89-94.
Sanders, R., et al., “Quantitative pH Imaging in Cells Using Confocal Fluorescence Lifetime Imaging Microscopy”,Analytical Biochemistry, vol. 227, Issue 2, Academic Press, Inc., 1995, p. 302-308.
Rojas, M., et al., “Genetic Engineering of Proteins with Cell Membrane Permeability”,Nature Biotechnology, vol. 16, 1998, p. 370-375.
GE Healthcare UK Limited
Gross Christopher M.
Ji Yonggang
Low Christopher
LandOfFree
Methods for measuring enzyme activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for measuring enzyme activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for measuring enzyme activity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4199475