Methods for making thebaine or its acid salts

Details Methods for making thebaine or its acid salts Methods for making thebaine or its acid salts

2005-10-25

2005-10-25

Solola, Taofig (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06958398

ABSTRACT:
Methods for making thebaine and an acid salt of thebaine are disclosed herein. In one embodiment, an acid salt of thebaine is made from codeinone or an acid salt of one or more of the following: 8-methoxy-Δ6-dihydrothebaine, codeinone dimethyl ketal, and neopinone dimethyl ketal.

REFERENCES:
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patent: 6090943 (2000-07-01), Mudryk et al.
patent: 1260 699 (1972-01-01), None
Choudhrey et al., 1989, “The Synthesis of Thebaine-1-3H,” J. Labell. Cmpd. Radiopharm. 27(12):1403-1408.
Coop et al., 1998, “A Novel Synthesis of Thebaine from Codeine,” Heterocycles 49:43-47.
Rapoport et al., 1967, “The Synthesis of Thebaine and Northebaine from Codeinone Dimethyl Ketal,” J. Amer. Chem. Soc. 89(8):1942-1947.
Seki et al., 1970, “Studies on the Morphine Alkaloids and Its Related Compounds. XVII. One-Step Preparations of Enol Ether and Pyrrolidinyl Dienamine of Normorphinone Derivatives,” Chem. Pharm. Bull. 18(4):671-676.
The Merck Index, 2001, 13thed., 9346.
Remington: The Science and Practice of Pharmacy, 2000, 20thed., p. 1448.

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