Methods for making HLA binding peptides and their uses

Details Methods for making HLA binding peptides and their uses Methods for making HLA binding peptides and their uses

1993-11-29

2000-03-14

Cunningham, Thomas M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 72, 530328, 4241851, C12Q 100, C12Q 2100

Patent

active

060371358

ABSTRACT:
Methods for making peptides comprising an HLA-A24.1-, HLA-A1-, HLA-A11-, and HLA-A3.2-restricted T cell epitope consisting of about 8-11 amino acid residues, and methods of making a peptide that binds to an HLA-A24.1, HLA-A1, HLA-A11, and HLA-A3.2 molecule at a dissociation constant of less than 500 nM.

REFERENCES:
Parham, P. et al., Immunological Reviews 143:141-180, The origins of HLA-A, B, C polymorphism, 1995.
Van Eden et al., Vaccines 89, pp. 33-337, A modified PEPSCAN method for the rapid identication and characterization of T-cell epitopes in protein antigens, 1989.
Van der Zee et al., Eur. J. Immunology 19:43-47, Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides, 1989.
Paul, W.F. et al., Fundamental Immunology, 4th edition, pp. 274-285, 1999.
Bruss, V. A short linear sequence in the pre-S domain of the large hepatitis B virus envelope protein required from virion formation. J. Virology. Dec. 1997, vol. 71, No. 12, pp. 9350-9357.
Preisler-Adams, S. et al. Complete nucleotide sequence of a hepatitis B virus, subtype adw2, and identification of three types of C open reading frame. Nucleic Acids Res. 1993, vol. 21, No. 9, p. 2258.
Rammensee, H. et al. Peptides naturally presented by MHC Class I molecules. Annu. Rev. Immunol. 1993, vol. 11, pp. 213-244.
Engelhard, V. et al. Structure of peptides associated with MHC Class I molecules. Curr. Opin. Immunol. 1994, vol. 6, pp. 13-23.
Urban, J.L., et al., "Autoimmune T Cells: Immune Recognition of Normal and Variant Peptide Epitopes and Peptide-Based Therapy," Cell 59:257-271 (Oct. 20, 1989).
Wraith, D.C., et al., "Antigen Recognition in Autoimmune Encephalomyelitis and the Potential for Peptide-Mediated Immunotherapy," Cell 59:247-255 (Oct. 20, 1989).
Parker, K.C., et al., Peptide Binding to HLA-A2 and HLA-B27 Isolated from Escherichia coli, J. Biol. Chem. 267(8):5451-5459 Mar. 15, 1992.
Morrison, J., et al., "Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA-A2 in its recognition by cytotoxic T lymphocytes," Eur. J. Immunol., 22:903-907 (1992).
Shimojo, N., et al., Specificity of Peptide Binding by the HLA-A2.1 Molecule, J. of Immunol. 143(9):2939-2947 (Nov. 1, 1989).
Carreno, B.M., et al, "HLA-B37 and HLA-A2.1 molecules bind largely nonoverlapping sets of peptides," Proc. Natl. Acad. Sci. USA, 87:3420-3424 (May 1990).
Henderson, R.A., et al., "HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation," Science 255:1264-1266 (Feb. 10, 1992).
Kannagi, M., et al., "Target Epitope in the Tax Protein of Human T-Cell Leukemia Virus Type I Recognized by Class I Major Histocompatibility Complex-Restricted Cytotoxic T Cells," J. of Virol. 66(5):2928-2933 (May 1992).
Falk, K., et al., "Allele-specific motifs revealed by sequenceing of self-peptide eluted from MHC molecules," Nature 351:290-296 May 23, 1991).
Jardetzky, T.S., et al., Identification of self peptides bound to purified HLA-B27, Nature 353:326-329 (Sep. 26, 1991).
Rotzschke, O., et al., "Naturally occurring peptide antigens derived from the MHC class-I-restricted processing pathway," Immunology Today 12(12):447-455 (1991).
De Bruijn, M.L.H., et al., Peptide loading of empty major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses, Eur. J. Immunol. 21:2963-2970 (1991).
Pamer, E.G., et al., "Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes," Nature 353:852-855 (Oct. 31, 1991).
Cordingley, et al., J.B.C. 265:9062-65, 1990.
Maryanski, J. L. et al., J. Exp. Med. 167:1391-1405, "Synthetic peptides as antigens and competitors in recognition by H2-restricted cytolytic T cell specific for HLA", Apr. 1988.
Hunt, D.F., et al., "Characterization of Peptides Bound to the Class I MHC Molecule HLA-A2.1 by Mass Spectrometry," Science, 255:1261-1263 (Mar. 6, 1992).
Maryanski, J. L. et al., Cell 60:63-72, "Competitor analogs for defined T cell antigens: peptides incorporating a putative binding motif and polyproline or polyglycine spacers", Jan. 12, 1990.
Patarroyo, M. E. et al., Nature 328:629-632, "Induction of protective immunity against experimental infection with malaria using synthetic peptides", Aug. 1987.
Parker, K. C. et al., J. Immunol. 149:3580-3587, "Sequence motifs important for peptide binding to human MHC Class I molecule, HLA-A2", Dec. 1992.
Kumar, V. et al., PNAS 87:1337-1341, "Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties", Feb. 1990.
Engelhard, V. H., Annu. Rev. Immunol. 1994, 12:181-207, "Structure of peptides associated with Class I and Class II MHC molecules", 1994.
W. F. Paul (ed.), Fundamental Immunology, 3rd edition (1993), pp. 617-619, Raven Press, New York.
W. F. Paul, Fundamental Immunology, 2nd Edition (1989), pp. 473-487.
Maryanski, J. L., et al. Cell 60:63-72 (Jan. 12, 1990).

Affiliated with

Also associated with

Rating

Methods for making HLA binding peptides and their uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for making HLA binding peptides and their uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for making HLA binding peptides and their uses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-168137