Surgery – Miscellaneous – Methods
Patent
1995-04-14
1998-11-17
Prebilic, Paul B.
Surgery
Miscellaneous
Methods
623 4, 623 5, 623901, 1562722, 156 60, 156 1, A61B 1900, A61F 214
Patent
active
058363130
ABSTRACT:
Methods for forming implantable composite keratoprostheses are provided. The methods provide keratoprostheses designed to provide a suitable substrate for corneal epithelial cell growth while maintaining the desirable characteristics of hydrogels, i.e., clarity, flexibility and the ability to allow diffusive flow of nutrients. In a preferred embodiment the method includes placing corneal tissue in a mold having a corneal implant shape and crosslinking a polymeric solution to chemically bond a biocompatible hydrogel having a thickness between approximately 50 and 100 microns to the corneal tissue to form the keratoprosthesis. Upon implantation, the corneal tissue abuts epithelial cells surrounding the keratoprosthesis. In another preferred embodiment, a polymer solution is placed between the corneal tissue and a pre-formed hydrogel and then polymerized so that the polymer solution couples to both the hydrogel and the corneal tissue.
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Merrill Edward W.
Miller David
Perez Edward
Massachusetts Institute of Technology
Prebilic Paul B.
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