Methods for making bis-heterocyclic alkaloids

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S490000, C548S493000, C514S415000, C514S419000

Reexamination Certificate

active

06841685

ABSTRACT:
Methods for making bis-heterocyclic compounds, especially bis-heterocyclic compounds having five and six-membered heterocyclic linkers are described. Also described are methods for making an alpha amino ketone synthon that enables facile syntheses of bisindole compounds, including topsentins and dragmacidins

REFERENCES:
patent: 5936098 (1999-08-01), Yasuda et al.
CAPLUS abstract of Hogan, I. T. and Sainsbury, M. The Synthesis of dendrodoine, 5-[3-(N,N-dimethylamino-1,2,4-thiadiazolyl]-3-indolylmethanone, a metabolite of the marine tunicate Dendroda grossular. Tetrahedron (1984). vol. 40 (4), pp 681-2.*
CAPLUS abstact of Ogura, Fumio et al. JP 63079848, Manufacture of carbonyl compounds by oxidation of hydroxyl compounds in the presence of aryl tellurinic acid anhydrides. Apr. 9, 1998.

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