Methods for making and delivering Rho-antagonist tissue...

Details Methods for making and delivering Rho-antagonist tissue... Methods for making and delivering Rho-antagonist tissue...

2003-11-24

2009-02-17

Kemmerer, Elizabeth C. (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C424S198100, C424S094500, C530S350000, C435S810000, C514S303000, C546S119000

Reexamination Certificate

active

07491692

ABSTRACT:
The present invention provides methods for making, delivering and using formulations that combine a therapeutically active agent(s) (such as for example a Rho antagonist(s)) and a flowable carrier component capable of forming a therapeutically acceptable matrix in vivo (such as for example tissue adhesives), to injured nerves to promote repair and regeneration and regrowth of injured (mammalian) neuronal cells, e.g. for facilitating axon growth at a desired lesion site. Preferred active agents are known Rho antagonists such as for example C3, chimeric C3 proteins, etc. or substances selected from among known trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds or Rho kinase inhibitors. The system for example may deliver an antagonist(s) in a tissue adhesive such as, for example, a fibrin glue or a collagen gel to create a delivery matrix in situ. A kit and methods of stimulating neuronal regeneration are also included.

REFERENCES:
patent: 4359049 (1982-11-01), Redl et al.
patent: 4631055 (1986-12-01), Redl et al.
patent: 4874368 (1989-10-01), Miller et al.
patent: 4978336 (1990-12-01), Capozzl et al.
patent: 4997834 (1991-03-01), Muro et al.
patent: 5900408 (1999-05-01), Block et al.
patent: 5922356 (1999-07-01), Koseki et al.
patent: 5945115 (1999-08-01), Dunn et al.
patent: 5989215 (1999-11-01), Delmotte et al.
patent: 6036955 (2000-03-01), Thorper et al.
patent: 6047861 (2000-04-01), Vidal et al.
patent: 6117425 (2000-09-01), MacPhee et al.
patent: 6121422 (2000-09-01), Zimmerman et al.
patent: 6124273 (2000-09-01), Drohan et al.
patent: 6218410 (2001-04-01), Uehata et al.
patent: 7141428 (2006-11-01), McKerracher
patent: 2300878 (1999-02-01), None
patent: 2304981 (1999-05-01), None
patent: 0956865 (1998-02-01), None
patent: WO98/06433 (1998-02-01), None
Zigmond, M.J., editor, 1999, Fundamental Neuroscience, Academic Press, pp. 526-543.
Houweling et al., Exp. Neurology 153: 49-59 (1998).
Masuda-Nakagawa, L., et al, 1993, PNAS, 90: 4966-4970.
Ramon-Cueto et al. Neuron 25:425-435 (2000).
Hauser, et al, 1993, J. Bacteriol., 175(22): 7260-7268.
Moriishi, et al, 1993, Infection and Immunity, 61(12): 5309-5314.
Omelchenko, et al, 2003, PNAS, 100(19): 10788-1079.
Spronk, et al, 2004, Thrombosis J., 2: 12-21.
Ten Berg, et al, 2001, Curr. Control. Trials Cardiovasc. Med., 2: 129-140.
Ishizaki, et al, 2000, Mol. Pharmacol., 57: 976-983.
Winton, et al, 2002, J. Biol. Chem., 277(36): 32820-32829.
Taniguchi-Sidle, et al, 1992, J. Biol. Chem, 287(1): 635-643.
Itoh, et al, 1999, Nature Medicine, 5(2): 221-225.
Blazso, et al, 2004, Phytother. Res., 18(7): 579-581.
Itano, et al, 2002, Proc. Natl. Acad. Sci., 99(6): 3609-3614.
Saito, et al, 1995, FEBS, 371: 105-109.
Boston life sciences, Sep. 6, 2000 Press release.
Aguayo , et al. , J. Exp. Biol.95:231-40 (1981).
Schwab et al. Annu. Rev. Neurosci. 16:565-595 (1993).
Schnell and Schwab Nature 343:269-272 (1990).
Weibel, et al. Brain Res 642:259-266 (1994).
Ramer, et al. Nature 403:312-316 (2000).
Liu, et al. J. Neurosci 19:4370-87 (1999).
Blesh, et al., J. Neurosci 19:3556-66 (1999).
Schnell, et al., Nature 367:170-173 (1994).
Neuman, Neuron 2383-91 (1999).
Cai, et al., Neuron 22:89-101 (1999).
Lehmann, et al. J. Neurosci 19:7537-7547 (1999).
Li, et al., J. Neurosci res. 46:404-414 (1996).
Fan, et al., J. Cell Biol. 121:867-878 (1993).
Tigyi, et al., Journal of Neurochemistry 66:537-548 (1996).
Kuhn, et al. J. Neurosci 19:1965-1975 (1999).
Jin and Strittmatter, J. Neurosci 17:6256-6263 (1997).
Zheng and Li, J. Biol. Chem. 272:4671-4679 (1999).
van Leeuwen, et al. J. Cell Biol. 139:797-807 (1997).
Nobes and Hall, Cell 1995,81:53-62 (1995).
Laudanna, et al., Science 271:981-983 (1996).
Hannigan, et al., Nature 379:91-96 (1996).
Kuhn, et al., J. Neurobiol. 37:524-540 (1998).
Hall, Ann. Rev. Cell. Biol. 10:31-54 (1996).
Kozma, et al., Molec. Cell. Biol. 17:1201-1211 (1997).
Albertinazzi, et al. J. Cell. Biol. 142:815-825 (1998).
Huthchens, et al. Molec. Biol. Cell 8:481-500 (1997).
Daniels, et al., EMBO Journal 17:754-764 (1998).
Sebok, et al. J. Neurochem 73:949-960 (1999).
Lang, et al., EMBO Journal 15:510-519 (1996).
Dong, et al., J. Biol. Chem 273:22554-22562 (1998).
Renaudin, et al., J, Neurosci Res. 55:458-471 (1998).
Dillon and Feigh, Methods in Enzymology: Small GTPases and their regulators Part. B.256:174-184 (1995).
Kimura and Schubert, Journal of Cell Biology 116:777-783 (1992).
Keino-Masu, et al., Cell. 87:175-185 (1996).
Matsui, et al., EMBO J. 15:2208-2216 (1996).
Matsui, et al., J. Cell Biol. 140:647-657 (1998).
Ishizaki, FEBS Lett. 404:118-124 (1997).
Vaheri, et al., Curr. Opin. Cell. Biol. 9:659-666 (1997).
Goslin, et al., J. Cell Biol. 109:1621-1631 (1989).
Hirose, et al., J. Cell Biol. 141:1625-1636 (1998).
Bito, Neuron 26:431-441 (2000).
Ishizali, et al., Molecular Pharacology 57:976-983 3 (2000).
Uehata, et al., Nature 389:990-994 (1997).
Somlyo, Nature 389:908-911 (1997).
Mansour-Robaey 1994 PNAS 91:1632-1636.
Guest, J. Neurosci Res. 50:888-905 (1997).
Verge, et al., Journal of Neuroscience 15;2081-2096 (1995).
Cheng, et al., Science, 273:510-513 (1996).
Joosten, J, Neurosci Res. 41:481-490 (1995).
Kennedy, et al., Cell. 78:425-435 (1994).
McKerracher, et al., Molec. Neurobiol. 12:95-116 (1996).
Diekmann and Hall, in Methods in Enzymology vol. 256 part B 207-215 (1995).
Xu, et al., Exp. Neurol 134:261-272 (1996).
Guest Exp. Neurol. 148:502-522 (1997).
Tuszynsli, et al., Cell Transplant 7:187-96 (1998).
Liu, et al., Exp. J. Neurosci. 19:4370-4387 (1999).
Tuszynski, et al., Exp. Neurol 126:1-14 (1994).
Nakahara, et al., Cell Transplant 5:191-204 (1996).
Diener and Bregman J. Neurosci 18:779-793 (1998).
Bregman, Exp. Neurol 123:2-16 (1993).
Lazarov-Spiegler, et al., FASEB J. 110:1296-1302 (1996).
McDonald, et al., Nat. Med. 5:1410-2 (1999).
Li, et al. Science 277:2000-2002 (1997).
Ramon-Cueto, et al., J. Neurosci 18:3803-15 (1998).
Herbert J. Biomed. Mater Res. 40:551-559 (1998).
Janknecht, et al., Proc. Natl. Acad. Sci. USA 88, 8972 (1981).
Beattie, Basso and Breshnahan, J. Neurotrauama 12:1-20 (1995).
Ridley and Hall, Cell. 70:389-399 (1992).
Popoff, et al., Nucl. Acid. Ress.18:1291 EMBL accession No. X511464 (1990).
Methods in Enzymology, vol. 256, Part B., Eds.; W.E. Balch, C.H. Der, and A. Hall. Academic Press, 1995.

Affiliated with

Also associated with

Rating

Methods for making and delivering Rho-antagonist tissue... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for making and delivering Rho-antagonist tissue..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for making and delivering Rho-antagonist tissue... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4109676