Methods for ligation of molecules to surfaces

Details Methods for ligation of molecules to surfaces Methods for ligation of molecules to surfaces

2007-08-14

2007-08-14

Russel, Jeffrey Edwin (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Chemical aftertreatment, e.g., acylation, methylation, etc.

C148S250000, C427S337000, C427S338000, C438S765000, C530S402000, C530S810000

Reexamination Certificate

active

10930702

ABSTRACT:
The present invention is a method for a covalent ligation of one or more molecules to one or more surfaces, that is site-specific and both rapid and high yielding. The covalent ligation to the surface is based on the reaction of an azide and a phosphinothioester to form an amide bond. The method of the invention is particularly well-suited to the immobilization of peptides, proteins or protein fragments to surfaces.

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