Methods for laser induced fluorescence intensity feedback contro

Details Methods for laser induced fluorescence intensity feedback contro Methods for laser induced fluorescence intensity feedback contro

1993-03-15

1994-09-27

Pellegrino, Stephen C.

Surgery

Instruments

Light application

606 15, 128634, 128898, A61B 1736

Patent

active

053503759

ABSTRACT:
Methods are provided for laser induced fluorescence intensity feedback and control during laser angioplasty. In a first aspect of the invention, a catheter including an eccentric guidewire lumen and at least one optical fiber is positioned relative to an obstruction in a blood vessel by rotating the catheter and monitoring the fluorescence intensity. When the fluorescence intensity has a maximum value, the optical fiber is aligned with the obstruction. In another aspect of the invention, fluorescence intensity feedback is used to determine when a laser ablation device has crossed an occlusion. An abrupt drop in fluorescence intensity indicates that the ablation device has crossed the occlusion. In a further aspect of the invention, fluorescence intensity feedback is used to determine the effectiveness of fluid flushing in a blood vessel. In yet another aspect of the invention, fluorescence spectroscopy and fluorescence intensity monitoring are performed sequentially for different subsets of optical fibers in a laser catheter to provide precise control over fiber positioning, tissue diagnosis and ablation. Preferably, the fluorescence intensity feedback is used in conjunction with fluorescence spectroscopy.

REFERENCES:
patent: 4718417 (1988-01-01), Kittrell et al.
patent: 4785806 (1988-11-01), Deckelbaum
patent: 5106387 (1992-04-01), Kittrell et al.
patent: 5115137 (1992-05-01), Andersson-Engels et al.
Deckelbaum et al., "In-Vivo Fluorescence Spectroscopy of Normal and Atherosclerotic Arteries", SPIE, vol. 906, Optical Fibers in Medicine III, 1988, pp. 313-319.

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