Methods for isolation and use of T cell epitopes eluted from via

Details Methods for isolation and use of T cell epitopes eluted from via Methods for isolation and use of T cell epitopes eluted from via

1997-01-15

2000-06-20

Huff, Sheela

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Cancer cell or component thereof

424 851, 424 9371, 435 701, 435 703, 435325, 435372, 435384, 435385, 435386, 514 2, 514 21, 530344, A61K 3512, A61K 3800, C12N 1585, C07K 500

Patent

active

06077519&

ABSTRACT:
Methods are provided for eluting peptides that are bound to major histocompatibility complex ("MHC") molecules expressed on the cell surfaces of viable cells that have at least one MHC-peptide complex on the surfaces of the cells. Methods are provided for using such acid-eluted T cell epitopes, preferably obtained from a patient's tumor, and autologous dendritic cells as the basis for antitumor vaccines.

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