Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification
Reexamination Certificate
2007-05-29
2007-05-29
Vogel, Nancy (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Reexamination Certificate
active
11235037
ABSTRACT:
Dominant-negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into mammalian cells new cell lines with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation or introduction of mutations by chemical mutagens. These methods are useful for generating novel and highly active antimicrobial molecules as well as superior antimicrobial agents from pre-existing chemicals. These methods are also useful for generating cell lines expressing novel antimicrobials that are useful for pharmaceutical manufacturing.
REFERENCES:
patent: 5885827 (1999-03-01), Wabl et al.
patent: 5907079 (1999-05-01), Mak et al.
patent: 6146894 (2000-11-01), Nicolaides et al.
patent: 6191268 (2001-02-01), Liskay et al.
patent: 6287862 (2001-09-01), delCardayre et al.
patent: 6576468 (2003-06-01), Nicolaides et al.
patent: 2240609 (1999-10-01), None
patent: WO 97/05268 (1997-02-01), None
patent: WO 98/07833 (1998-02-01), None
patent: WO 99/19492 (1999-04-01), None
Alderson, G. et al., “Physiology and genetics of antibiotic production and resistance”,Res. Microbiol.,1993, 144, 665-672.
Allen, D., et al., “MutS mediates heteroduplex loop formation by a translocation mechanism,”EMBO J., 1997, 16(14), 4467-4476.
Aronshtam, A., et al. “Dominant negative mutator mutations in the mutl gene ofEscherichia coli”, Nucleic Acids Research,1996, 24(13), pp. 2498-2504.
Baker, S.M., et al., “Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis,”Cell,1995, 82, 309-319.
Bell, C.J., et al., “Assignment of 30 microsatellite loci to the linkage map ofarabidopsis,” Genomics,1994, 19, 137-144.
Bevins, C.L., et al., “Antimicrobial Peptides”, Ciba Foundation Symposium 186, John Wiley & Sons, 1994.
Bjornson, K., et al., “Modulation of MutS ATP hydrolysis by DNA cofactors,”Biochemistry,2000, 39, 3176-3183.
Bronner C.E., et al., “Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer,”Nature,1994, 368, 258-261.
Cascalho M, et al. “Mismatch repair co-opted by hypermutation”,Science,1998, 279(20), pp. 1207-1210.
Chakravarti, D. et al., “Relating aromatic hydrocarbon-induced DNA adducts and c-H-rasmutations in mouse skin papillomas: The role of apurinic sites”,Proc. Natl. Acad. Sci. USA,Oct. 1995, vol. 92, pp. 10422-10426.
Culligan, K.M., et al., “DNA mismatch repair in plants,”Plant Physiol.,1997, 15, XP-002099372, 833-839.
de Wind, N., et al., “Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer,”Cell,1995, 82, 321-330.
Drummond, J.T., et al., “Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells,”Science,1995, 268, 1909-1912.
Drummond, J.T., et al., “Cisplatin and adriamycin resistance are associated with mutlα and mismatch repair deficiency in an ovarian tumor cell line,”J. Biological Chemistry,1996, 271(33), 19645-19648.
Edelmann, W., et al., “Meiotic pachytene arrest in MLH1-deficient mice,”Cell,1996, 85, 1125-1134.
Eshleman, J.R., et al., “Mismatch repair defects in human carcinogenesis,”Human Molecular Genetics,1996, 5, 1489-1494.
Fishel, R., et al., “The Human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer,”Cell,1993, 7, 1027-1038.
Galio, L., et al., “ATP hydrolysis-dependent formation of a dynamic ternary nucleoprotein complex with MutS and MutL,”Nucleic Acids Research,1999, 27(11), 2325-2331.
Jean, M., et al., “Isolation and characterization ofAtMLH1,aMutLhomologue fromArabidopsis thaliana,” Mol. Gen. Genet.,1999, 262, XP-000986134, 633-642.
Harfe, B.D., “DNA mismatch repair and genetic instability,”Annu. Rev. Genet.,2000, 34, 359-399.
Hamilton, S.R., et al., “The molecular basis of turcot's syndrome,”N. Eng. J. Med.,1995, 332(13), 839-847.
Hoang J., et al., “BAT-26, an Indicator of the Replication Error Phenotype in Colorectal Cancers and Cell Lines”,Cancer Res.,1997, 57, 300-303.
Honma, M. et al., “Cytotoxic and Mutagenic Responses to X-rays and Chemical Mutagens in Normal and p53-mutated Human Lymphoblastoid Cells”,Mut. Res.,1997, 374, 89-98.
Huttner, K.M. et al., “Antimicrobial Peptides as Mediators of Epithelial Host Defense”,Pediatr. Res.,1999, 45(6), 785-794.
Jiricny, J., et al., “Mismatch repair defects in cancer,”Curr. Opin. Genet. Dev.,2000, 10, 157-161.
Kang, Y.K., et al., “Synthesis and Antibacterial Activity of New Carbapenems Containing Isoxazole Moiety”,Bioorg. Med. Chem. Lett.,2000, 10(2), 95-99.
Karran, P., et al., “Genomic instability and tolerance to alkylating agents,”Cancer Surveys,1996, 28, 69-71.
King, D.E. et al., “New Classification and Update on the Quinolone Antibiotics”,Am. Fam. Physician,2000, 61(9), 2741-2748.
Kong, Q., “PMS2-deficiency diminishes hypermutation of a λ1transgene in young but not older mice,”Molecular Immunology 36,1999, 83-91.
Leach, F.S., et al., “Mutations of mutS homolog in hereditary nonpolyposis colorectal cancer,”Cell, 1993, 75, 1215-1225.
Lipkin, S.M., et al., “MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability,”Nature Genetics,2000, 24, XP-002165243, 27-35.
Liu, T., et al., “Microsatellite instability as a predictor of a mutation in a DNA mismatch repair gene in familial colorectal cancer,”Genes, Chromosomes&Cancer,2000, 27, 17-25.
Liu et al., “Analysis of Mismatch Repair Genes in Hereditary Non-polyposis Colorectal Cancer Patients”,Nature Medicine,Feb. 1996, 2(2), 169-174.
Ma et al., “Dominant Negative Expression of hpMS2 Creates Isogenic Mismatch Repair Deficient Human Colon Cancer Cell Lines ”,Proc. Am. Assoc. Cancer Res.,Mar. 1998, 39, p. 460 (Abstract #3130).
Matsuzaki K., “Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes”,Biochim. Biophys. Acta,1999, 1462(1-2), 1-10.
McCallum, C.M., “Targeted screening for induced mutations,”Nature Biotechnology,2000, 18, 455-457.
Modrich, P., “Mismatch repair, genetic stability, and cancer,”Science,1994, 266, 1959-1960.
Neuberger, M., et al., “Mice perform a human repertoire,”Nature,1997, 386, 25-26.
Nicolaides, N.C., et al., “The jun family members, c-jun and junD, transactivate that human c-myb, promotor via an Apl-like element,”J. Biological Chemistry,1992, 267(27), 19655-19672.
Nicolaides, N.C., et al., “Genomic organization of the humanPMS2 gene family,”Genomics,1995, 30, 195-206.
Nicolaides, N.C., et al., “Positive autoregulation of c-myb,expression via Myb binding sites in the 5′ flanking region of the human c-mybgene,”Molecular and Cellular Biology,1991, 11(12), 6166-6176.
Nicolaides, N.C., “A naturally occuringhPMS2 mutation can confer a dominant negative nutator phenotype,”Mol. Cell. Biol.,1998, 18(3), 1635-1641.
Nicolaides, N.C., et al., “Analysis of the 5′ region ofPMS2 reveals heterogeneous transcripts and a novel overlapping gene,”Genomics,1995, 29, 329-334.
Nicolaides, N.C., et al., “Mutations of two PMS homologues in hereditary nonpolyposis colon cancer,”Nature,1994, 371, 75-80.
Nicolaides, N.C., et al., “Molecular cloning of the N-Terminus of GTBP,”Genomics,1996, 31, 395-397.
Palombo, F., et al., “Mismatch repair and cancer,”Nature,1994, 367, 417.
Papadopoulos, N., et al., “Mutation of amutLhomolog in hereditary colon cancer,”Science,1994,
Grasso Luigi
Nicolaides Nicholas C.
Sass Philip M.
Morphotek Inc.
Vogel Nancy
Woodcock & Washburn LLP
LandOfFree
Methods for isolating novel antimicrobial agents from... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for isolating novel antimicrobial agents from..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for isolating novel antimicrobial agents from... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3734550