Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1993-07-21
1996-01-02
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514449, 549510, A61K 3578, A61K 31335
Patent
active
054806399
ABSTRACT:
Methods of obtaining renewable sources of taxanes including taxol are provided. Compositions comprising taxanes which are useful as source materials for the further purification of taxanes are also disclosed. Specifically, a method of drying plant matter to preserve their taxane content and facilitate their extraction is disclosed. In addition, methods of extracting and purifying taxol and other taxanes from ornamental cultivars using a series of organic and aqueous solvents and normal phase chromatography columns are also disclosed.
REFERENCES:
patent: 4206221 (1980-06-01), Miller et al.
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 5019504 (1991-05-01), Christen et al.
Natural Products Branch, National Cancer Institute, description of taxol dated Jul. 15, 1983.
Wani, et al., "Plant Antitumor Agents. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus breifolia", J. Am. Chem. Soc. 93:2325 (1971).
Bailey, et al. "A Concise Dictionary of Plants Cultivated in the United States and Canada", Hortus Third, pp. ix-xiii and 1098-1099 (1976).
Miller, R. W., "A Brief Survey of Taxus Alkaloids and other Taxane Derivatives", J. Natural Prod., 43:425-437 (1980).
Miller, et al. "Antileudemic Alkaloids from Taxus wallichiana Zucc", J. Org. Chem., 46:1469-1474 (1981).
McLaughlin, et al., "19-Hydroxybaccatin III, 10-Deacetylcephalomannine, and 10-Deacetyltaxol: New Anti-Tumor Taxanes from Taxus Wallichiana", Journ. of Natural Products, 44:312-319 (1981).
Senih, et al., "Mise En Evidence De Nouveaux Analogues Du Taxol Extraits de Taxus Baccata", Journ. of Natural Products, 47:131-137 (1984).
Witherkup, et al., "High Performance Liquid Chromatographic Separation of Taxol and Related Compounds From Taxus Brevifolia", Journ. of Liquid Chromatography, 2117-2132 (1989).
Witherup, et al., "Taxus Spp. Needles Contain Amounts of Taxol Comparable To The Bark of Taxus brevifolia: Analysis and Isolation", Journ. of Natural Products, 53:1249-1255 (1990).
Rowinsky, et al., "Taxol: A Novel Investigational Antimicrotuble Agent", Journ. of the National Cancer Institute, 82:1247-1259 (1990).
Vanhaelen--Fastre, et al., "High-Speed Countercurrent Chromtaography Separation of Taxol and Related Diterpenoids From Taxus Baccata", Journal of Liquid Chromatography, vol. 15, No. 4, 1992, pp. 697-706.
Harvey, et al., "Separation of Taxol From Related Taxanes in Taxus Brevifolia Extracts by Isocratic Elution Reversed-Phase Microcolumn High-Performance Liquid Chromatography", Journal of Chromatography, vol. 587, 1991, Amsterdam NL, pp. 300-305.
Zongping Zhang, et al., "New Taxanes from Taxus Chinensis", Planta Med., vol. 56, 1990 N.Y., pp. 293-294.
Croom, Jr. Edward M.
ElSohly Hala N.
ElSohly Mahmoud A.
McChesney James D.
Gitomer Ralph
The University of Mississippi
White John P.
Wityshyn Michael G.
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