Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-02-21
2006-02-21
Wilson, James O. (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S018500, C536S018600, C536S123100, C536S124000, C536S023200, C536S023500, C536S023100, C435S068100, C435S206000, C435S195000, C435S006120, C435S069100, C435S018000, C435S193000, C435S196000, C435S208000, C435S069700, C435S097000, C424S094610, C424S155100, C424S179100, C424S183100, C530S350000
Reexamination Certificate
active
07001994
ABSTRACT:
Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose 6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl groups on oxidized glycans of glycoproteins while retaining their biological activity are described. The methods are useful for modifying glycoproteins, including those produced by recombinant protein expression systems, to increase uptake by cell surface receptor-mediated mechanisms, thus improving their therapeutic efficacy in a variety of applications.
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Finnegan Henderson Farabow Garrett & Dunner LLP
Genzyme Corporation
Khare Devesh
Linnik Konstantin M.
Wilson James O.
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