Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2004-01-27
2008-08-05
Bartoglio, Valarie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S020000, C424S009200, C424S009100, C424S009600, C435S004000, C435S007100, C435S007230
Reexamination Certificate
active
07408095
ABSTRACT:
Methods of introducing heterologous cells into fish are provided. After introduction cells remain viable, and in some instances proliferate, for sufficient time to conduct a variety of analyses on the heterologous cells or the fish or both. Such methods are also useful, for example, for diagnosing the presence of small quantities of cancerous cells or pathogens in patient tissue samples.
REFERENCES:
patent: 4220858 (1980-09-01), Ikeguchi et al.
patent: 4286983 (1981-09-01), Van Gilse et al.
patent: 4816392 (1989-03-01), Hokama
patent: 4964615 (1990-10-01), Mueller et al.
patent: 5326692 (1994-07-01), Brinkley et al.
patent: 5491084 (1996-02-01), Chalfie et al.
patent: 5506208 (1996-04-01), Eyal et al.
patent: 5510099 (1996-04-01), Short et al.
patent: 5565187 (1996-10-01), Zikria et al.
patent: 5573909 (1996-11-01), Singer et al.
patent: 5658751 (1997-08-01), Yue et al.
patent: 5672470 (1997-09-01), Hengstenberg et al.
patent: 5681703 (1997-10-01), Tomei
patent: 5744499 (1998-04-01), Quash et al.
patent: 5932418 (1999-08-01), Yager
patent: 5981218 (1999-11-01), Rio et al.
patent: 2003/0149996 (2003-08-01), Wengler
patent: 2 080 948 (1982-02-01), None
patent: WO 96/03034 (1996-02-01), None
patent: WO 98/31787 (1998-07-01), None
patent: WO 98/58963 (1998-12-01), None
Koya, Y et al 2004, Zoological Science, 21:565-573.
Hatta, K. and Takahashi, Y., “Secondary axis induction by heterospecific organizers in zebrafish,”Dev. Dynamics,205:183-195 (1996).
Ho, R. and Kane, D., “Cell-autonomous action of zebrafishspt-1mutation in specific mesodermal precursors,”Nature,348:20-27 (Dec. 1990).
Sakai, D. K. et al., “Blood type compatibility of lower vertebrates: phylogenetic diversity in blood transfusion between fish species,”Dev. and Comparative Immunol.,11:105-115 (1987).
Yang, E. et al., “Norcantharidin inhibits growth of human HepG2 cell-transplanted tumor in nude mice and prolongs host survival,”Cancer Lett.,117:93-98 (1997).
Amsterdam et al., “Requirements for green fluorescent protein detection in transgenic zebrafish embryos”, Gene, 173: 99-103 (1996).
Armant et al., “Exposure of Embryonic Cells to Alcohol: Contrasting Effects During Preimplantation and Postimplantation Development”, Seminars in Perinatology, 20(2): 127-139 (Apr. 1996).
Bakkers et al., “An important developmental role for oligosaccharides during early embryogenesis of cyprinid fish”, Pro. Natl. Acad. Sci. USA, 94: 7982-7986 (Jul. 1997).
Baumann et al., “Bipartite Axiation Follows Incomplete Epiboly in Zebrafish Embryos Treated With Chemical Teratogens”, The Journal of Experimental Zoology, 230: 363-376 (1984).
Bechter et al., “Teratogenicity of arotinoids (retinoids): comparison of the whole embryo culture system with the in vivo mouse model and the limb bud cell culture assay”, Teratol. 44: 29A, #P33 (1991).
Becker et al., “Teratogenic Actions of Ethanol in the Mouse: A Minireview”, Pharmacol. Biochem. Behav., 55(4): 501-513 (1996).
Birge et al., “Acetaminophen Hepatotoxicity: Correspondence of Selective Protein Arylation in Human and Mouse Liver in Vitro, in Culture, and in Vivo”, Toxicol. Applied Pharmacol., 105: 472-482 (1990).
Boehm, et al., “Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance”, Nature, 390: 404-407 (1997).
Bonn, “Blocking angiogenesis in diabetic retinopathy”, Lancet, 348: 604 (1996).
Breier et al., “Angiogenesis in Embryos and Ischemic Diseases”, Thromb. Haemost., 78(1): 678-683 (1997).
Bresch,. “Early Life-Stage Test in Zebrafish versus a Growth Test in Rainbow Trout to Evaluate Toxic Effects”, Bull. Environ. Contam. Toxicol., 46: 641-648 (1991).
Buchmann et al., “Immunohistochemical Localization of the Cytochrome P450 Isozymes LMC2 and LM4B (P4501A1) in 2,3,7,8-Tetrachlorodibenzo-ρ-dioxin Treated Zebrafish (Brachyanio rerio)”, Toxicol. Appl. Parmacol. 123: 160-169 (1993).
Chen et al., “Mutations affecting the cardiovascular system and other internal organs in zebrafish”,Development.123: 293-302 (1996).
Chatot et al., “Successful Culture of Rat Embryos on Human Serum: Use in the Detection of Teratogens”, Science , 207: 1471-1473 (1980).
Chow et al., “The nuclear receptor transcription factor, retinoid-related orphan receptor , regulates retinal progenitor proliferation”, Mech. Dev., 77(2): 149-164 (1998).
Cicurel et al., “Post-implantation embryo culture: validation with selected compounds for teratogenicity testing”, Xenobiotica, 18(6): 617-624 (1988).
Clarke, “Developmental cell death: morphological diversity and multiple mechanisms”,Anat. Embryol., 181: 195-213 (1990).
Collodi et al., “Induction of zebrafish (Brachydanio rerio) P450 in vivo and in cell culture”,Xenobiotica, 24(6): 487-493 (1994).
Couffinhal et al., “Animal Model, Mouse Model of Angiogenesis”,Am. J. Pathol., 152(6): 1667-1679 (Jun. 1998).
Dawson, “Additive Incidence of Developmental Malformation forXenopusEmbryos Exposed to a Mixture of Ten Aliphatic Carboxylic Acids”, Teratology, 44: 531-546 (1991).
Debus et al., “Nematode Test to Estimate the Hazard Potential of Solved Contaminations”,Chemosphere, 29(3): 611-621 (1994).
Drake et al., “Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization”,Proc. Natl. Acad. Sci. U.S.A., 92: 7657-7661 (Aug. 1995).
Driever et al., “Zebrafish: genetic tools for studying vertebrate development,”TIG, 10(5): 152-159 (1994).
Dubois et al., “DNA adducts and P450 induction in human, rat and avian liver cells after exposure to polychlorobiphenyls”,Mutation Res., 345: 181-190 (1995).
Dumont et al., “Vascularization of the Mose Embryo: A Study offlk-1,tek, tie,and Vascular Endothelial Growth Factor Expression During Development”,Development Dynamics, 203: 80-92 (1995).
Eisses, “Teratogenicity and Toxicity of Ethylene Glycol Monomethyl Ether (2-Methoxyethanol) inDrosophila melanogaster. Involvment of Alcohol Dehydrogenase Activity”,Teratog. Carcinog. Mutagen., 9: 315-325 (1989).
Ellies et al., “Specific craniofacial cartilage dysmorphogenesis coincides with a loss ofdixgene expression in retinoic acid-treated zebrafish embryos”,Mechanisms of Development, 61: 23-36 (1997).
Ensenbach et al., “Toxicity of Complex Chemical Mixtures: Acute and Long-Term Effects on Different Lif e Stages of Zebrafish (Brachydanio rerio)”,Ecotoxicology and Environmental Safety, 30:151-157 (1995).
Feucht et al., “VEGF Induces Cardiovasuclar Malformation and Embryonic Lethality”,Am. J. Pathology, 151(5):1407-1416 (Nov. 1997).
Folkman, “Clinical Applications of Research on Angiogenesis”,N. Eng. J. Med., 333(26): 1757-1763 (Dec. 28, 1995).
Fort et al., “Phase III Interlaboratory Study of Fetax, Part 2: Interlaboratory Validation of an Exogenous Metabolic Activation System for Frogg Embryo Teratogenesis Assay-Xenopus (Fetax)”,Drug and Chem. Toxicol., 21(1): 1-14 (1998).
Fouquet et al., “Vessel Patterning in the Embryo of the Zebrafish: Guidance by Notochord”,Developmental Biology, 183: 37-48 (1997).
Frank et al., “Residues of Insecticides, Fungicides, and Herbicides on Ontario-Grown Vegetables, 1980-1985”,J. Assoc. Off. Anal. Chem., 70(6): 1081-1086 (1987).
Gavrieli et al., “Identification of Programmed Cell Death In Situ via Specific Labeling of Nuclear DNA Fragmentation”,J. Cell Biol., 119(3): 493-501 (Nov. 1992).
Granato et al., “Fishing for genes controlling development”,Cur. Op. Gen. Dev., 6: 461-468 (1996).
Guest et al., “Evaluation of the rat embryo culture system as a predictive test for human teratogens”,Can. J. Physiol. Pharmacol., 72: 57-62 (1994).
Hammerschmidt
McGrath Patricia
Serbedzija George N.
Bartoglio Valarie
Phylonix Pharmaceuticals, Inc.
Townsend and Townsend / and Crew LLP
LandOfFree
Methods for introducing heterologous cells into fish to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for introducing heterologous cells into fish to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for introducing heterologous cells into fish to... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4010719