Methods for inhibiting rejection of transplanted tissue

Details Methods for inhibiting rejection of transplanted tissue Methods for inhibiting rejection of transplanted tissue

1993-08-26

1998-07-21

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Hemic or immune system

424 858, 424534, 4241441, 530350, 530395, 435 2, A61K 3526, A61K 39395, C07K 100, C07K 1400

Patent

active

057832161

ABSTRACT:
A method for inhibiting rejection by a recipient animal of a transplanted tissue, said method comprising modifying, eliminating, or masking an antigen which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response in said animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of said animal without causing lysis of said cell.

REFERENCES:
patent: 5190859 (1993-03-01), Dustin et al.
patent: 5284931 (1994-02-01), Springer et al.
Zijlstra, et al, 1990, "B.sub.2 -Microglobulin Deficient Mice . . . " Nature 344:742-746.
Stock, et al, 1989, "Modulation of MHC Class I . . . " J. Surgical Res. 46:317-321.
Bishop, et al, 1989, "Expression of Lemcocyte . . . " Kidney International 36:1078-1085.

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