Methods for inhibiting rejection of transplanted tissue

Details Methods for inhibiting rejection of transplanted tissue Methods for inhibiting rejection of transplanted tissue

1991-03-19

1994-02-01

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

424 858, A61K 3900

Patent

active

052830586

ABSTRACT:
A method for inhibiting rejection by a recipient animal of a transplanted tissue, said method comprising modifying, eliminating, or masking an antigen which, when present on the surface of a cell of said tissue, is capable of causing a T-lymphocyte-mediated response in said animal, to inhibit antigen-mediated interaction between said cell and a T-lymphocyte of said animal without causing lysis of said cell.

REFERENCES:
Lacy, et al., 1979 "Prolongation of islet allograft survival . . ." Science 204: 312-313.
Faustman, et al., 1980 "Murine pancreatic B-cells express . . ." J. Exp. Med. 151:1563-1568.
Bishop, et al., 1989 "Expression of leucocyte and lymphocyte . . ." Kidney Int. 36: 1078-1085.
Stock et al., Journal of Surgical Research, vol. 46, pp. 317-321 (1989).
Winearls et al., Transplantation, vol. 28, pp. 36-39 (1979).

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