Methods for inhibiting inflammatory ischemic, thrombotic and cho

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 59, 514249, 514260, 514346, 514458, 514474, 514494, 514501, 514532, 514550, 514559, 514725, 514727, 424641, 424702, A61K 31195, A61K 3120

Patent

active

050844822

ABSTRACT:
This invention concerns novel methods employing compositions containing as an active antioxidant or antiinflammatory agent the amino acid methionine, and/or one or more related compounds including certain metabolic precursor compounds, for treating or inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response in a subject. The compounds include the methionine hydroxy analogs, as well as compounds having the structural formula I: ##STR1## and pharmaceutically acceptable N-(mono- and di-carboxylic acid) acyl derivatives and alkyl esters thereof, where n is an integer from 1 to 3.

REFERENCES:
patent: 3952115 (1976-04-01), Damico et al.
patent: 4315028 (1982-02-01), Scheinberg
patent: 4711780 (1987-12-01), Fahim
patent: 4927850 (1990-05-01), Bayless et al.
Gualano, Pharmacol Research Comm 15:683-96 (1983).
Flynn et al., Inflammation 8:33-44 (1984).
Poston et al., Atherosclerosis 19:353-67 (1974).
Ambanelli, U., Sposni, A., Ferraccioli, G., Serum Antioxidant Activity and Related Variables in Rheumatoid Arthritis, Scand. J. Rheumatology, 11: 203-7, 1982.
Ames, B., Dietary Carcinogens and Anticarcinogens, Science, 221: 1256-64, 1983.
Bailey, K., Sheffner, A., The Reduction of Experimentally Induced Inflammation by Sulfhydryl Compounds, Biochemical Pharmacology, 16: 1175-82, 1967.
Baldessarini, R., Stramentionoli, G., Lipinski, J., Methylation Hypothesis, Archives of General Psychiatry, 36: 303-7, 1979.
Brattstrom, L., Israelsson, B., Jeppsson, J. Hultberg, B., Folic acid--an innocuous means to reduce plasma homocysteine, Scand. J. Clin. Lab. Invest., 48: 215-21, 1988.
Braughler, J., Hall, E., Central Nervous System Trauma and Stroke I Free Radical Biology & Medicine, 6: 289-301, 1989.
Carp, H., Mitochondrial N-Formylmethionyl Proteins as Chemoattractants for Neutrophilis, J. Exp. Medicine, 155:264-75, 1982.
Cho., E., Andersen, B., Filer, L., Stegink, L. D-Methionine Utilization in Young Miniature Pigs, Adult Rabbits, and Adult Dogs, J. Parenteral and Enteral Nutrition, 4: 544-7, 1980.
Connor, H., Newton, D., Preston, R., Woods, H., Oral Methionine Loading as a Cause of Acute Serum Folate Deficiency: Its Relevance to Parenteral Nutrition, Postgraguate Medical J., 54: 318-20, 1978.
Cross., C., Halliwell, B., Borish, E., Pryor, W., Ames, B., Saul, R., McCord, J., Harman, D., Oxygen Radicals and Human Disease, Annals of Internal Medicine, 107: 526-45, 1987.
Cuperus, R., Muijsers, A., Wever, R., Antiarthritic Drugs Containing Thiol Groups Scavenge Hypochlorite and Inhibit its Formation by Myeloperoxidase from Human Leukocytes, Arthritis and Rheumatism, 28: 1228-33, 1985.
Cybulsky, M., Chan., M., Movat, H., Acute Inflammation and Microthrombosis Induced by Endotoxin, Interleukin-1, and Tumor Necrosis Factor and their Implication in Gram-Negative Infection. Laboratory Investigation, 58: 365-78, 1988.
Davis., R., Inhibition of Inflammation with Certain Amino Acids, J. of the Am. Podiatry Assoc., 68: 24-30, 1978.
Delrieu, F., Ferrand, B., Amor, B., Etude Preliminaire de La L-Methionine dans le Traitement de La Polyarthrite Rhumatoide, Revue du Rhumatisme, 55: 995-7, 1988.
Eisenhauer, L., Gerald, M., The Nurse's 1984-85 Guide to Drug Therapy, Prentice-Hall, New Jersey, 1984, pp. 247-65, and 584-602.
Figge, H., Figge, J., Souney, P., Mutnick, A., Sachs, F., Nicotinic Acid: A Review of its Clinical Use in the Treatment of Lipid Disorders, Pharmacotherapy, 8: 287-94, 1988.
Fleisher, L., Gaull, G., Methionine Metabolism in Man: Development and Deficiencies, Clinics in Endocrinology and Metabolism, 3:37-55, 1974.
Flynn, P., Becker, W., Vercellotti, G., Weisdorf, D., Craddock, P., Hammerschmidt, D., Lillehei, R., Jacob, H., Ibuprofen Inhibits Granulocyte Responses to Inflammatory Mediators. Inflammation 8: 33-44, 1984.
Gualano, M., Stramentinoli, G., Berti, F., Anti-Inflammatory Activity of S-Adenosyl-L-Methionine: Interference with the Eicosanoid System Pharmacological Research Communications, 15: 683-96, 1983.
Hall, E., Braughler, J., Central Nervous System Trauma and Stroke II. Free Radical Biology & Medicine, 6: 303-13, 1989.
Hall, N., Blake, D., Bacon, P., Serum Sulphydryl Levels in Early Snyovitis, J. of Rheumatology, 9: 593-6, 1982.
Inoue, Y., Zama, Y., Suzuki, M., D-Amino Acids as Immunosuppressive Agents, Japanese J. Exp. Medicine, 51: 363-6, 1981.
Johnson, J., Sustained Release Medications, Noyes Data Corp., New Jersey, 1980, p. 14.
Kies, C., Fox, H., Aprahamian, S., Comparative Value of L-, DL--, and D-Methionine Supplementation of an Oat-based Diet for Humans, J. of Nutrition, 105: 809-14, 1975.
Malinow, M., Kang., S., Taylor, L., Wong., P., Coull, B., Inahara, T., Mukerjee, D., Sexton, G., Upson, B., Prevalence of Hyperhomocyst(e)inemia in Patients with Peripheral Arterial Occlusive Disease, Circulation, 79: 1180-8, 1989.
Marcolongo, R., Giordano, N., Colombo, B., Cherie-Ligniere, G., Todesco, S., Mazzi, A., Mattara, L., Leardini, G., Passeri, M., Cucinotta, D., Double-Blind Multicentre Study of the Activity of S-Adenosyl-Methionine in Hip and Knee Osteoarthritis, Current Therapeutic Research, 37: 82-94, 1985.
McKenna, F., Hickling P., Kixon, J., Bird, H., Methylcycsteine in Rheumatoid Arthritis, Br. J. of Rheumatology, 25: 132, 1986.
Middeke, M., Holzgreve, H., Review of Major Intervention Studies in Hypertension and Hyperlipidemia: Focus on Coronary Heart Disease, Am. Heart J., 116: 1708-12, 1988.
Montgomery, R., Dryer, R., Conway, T., Spector, A., Biochemistry: A Case-Oriented Approach Mosby Co., St. Louis, 4th Ed., 1983, pp. 466-70.
Munro, J., Cotran, R., The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation, Laboratory Investigation, 58: 249-61, 1988.
O'Brien, J., Destruction of Elastic Tissue (Elastolysis) as a Link between Atherosclerosis and the Temporal Arteritis/Polymyalgia Rheumatica Syndrome, Pathologie Biologie, 32: 123-38, 1984.
Olszewski, A., Szostak, W., Homocysteine Content of Plasma Proteins in Ischemic Heart Disease, Atherosclerosis, 69: 109-13, 1988.
Plow, E., Edgington, T., I. The Cleavage of Fibrinogen by Leukocyte Proteases at Physiologic pH, J. of Clinical Investigation, 56: 30-8, 1975.
Poston, R., Davies, D., Immunity and Inflammation in the Pathogenesis of Atherosclerosis, Atherosclerosis, 19: 353-67, 1974.
Reinhold, J., Lahimgarzadeh, A., Nasr, K., Hedayati, H., Effects of Purified Phytate and Phytate-Rich Bread upon Metabolism of Zinc, Calcium, Phosphorus, and Nitrogen in Man, The Lancet, Feb. 10, 1973, pp. 283-8.
Remington's Pharmaceutical Sciences, Gennaro, A., Editor. Phil. College of Pharm. and Sci., 17th Edition, 1985, pp. 773-85, 819-23, 1542-50, 1585-602.
Ross, R., The Pathogenesis of Atherosclerosis--an Update, New Eng. J. of Medicine, 314: 488-500, 1986.
Rotruck, J., Boggs, R., Comparative Metabolism of L-Methionine and N-Acetylated Derivatives of Methionine, J. Nutrition, 105: 331-7, 1975.
Rubin, R., Ordonez, L., Wurtman, R., Physiological Dependence of Brain Methionine and S-Adenosyl-Methionine Concentration on Serum Amino Acid Pattern, J. of Neurochemistry, 23: 227-31, 1974.
Sarwar, G., Peace, R., Comparisons between True Digestibility of Total Nitrogen and Limiting Amino Acids in Vegetable Proteins Fed to Rats, J. of Nutrition, 116: 1172-84, 1986.
Schlievert, P., Shands, K., Dan, B., Schmid, G., Nishimura, D., Identification and Characterization of an Exotoxin from Staphylococcus aureus Associated with Toxic-Shock Syndrome, J. of Infectious Diseases, 143: 509-16, 1981.
Spector, W., An Introduction of General Pathology, 2nd Edition, Churchill Livingstone, New York, 1980, pp. 58-75.
Stegink, L., Bell, E., Filer, L., Siegler, E., Andersen, D., Seligson, F., Effects of Equimolar Doses of L-Methionine, D-Methionine and L-Methionine-dl-Sulfoxide on Plasma and Urinary Amino acid Levels in Normal Adult Humans, J. Nutrition, 116: 1185-92, 1986.
Stegink, L., Filer, L., Baker G., Plasma Methionine Levels in Normal Adult Subjects after Oral Loading with L-Methionine and N-Acetyl-L-Methionine, J. Nutrition, 110: 42-9, 1980.
Stendahl, O., Coble, B., Dahlgren, C., Hed, J., Molin, L., Myeloperoxidase Modulates the Phagocytic

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for inhibiting inflammatory ischemic, thrombotic and cho does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for inhibiting inflammatory ischemic, thrombotic and cho, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for inhibiting inflammatory ischemic, thrombotic and cho will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1861270

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.