Methods for inhibiting immunostimulatory DNA associated...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C524S187000

Reexamination Certificate

active

07354711

ABSTRACT:
The invention features methods for inhibiting immunostimulatory DNA-associated immune responses, through the administration of specific compounds of the general class of 9-aminoacridines and 4-aminoquiniolines. The invention also features methods of screening compounds useful in inhibiting immunostimulatory DNA-induced immune responses.

REFERENCES:
patent: 2233970 (1941-03-01), Andersag et al.
patent: 5583153 (1996-12-01), Brahn
patent: 5641868 (1997-06-01), Sakurai et al.
patent: 6207646 (2001-03-01), Krieg et al.
patent: 6225292 (2001-05-01), Raz et al.
Yi et al. CpG DNA rescue of murine B lymphoma cells from anti-IgM induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xl The Journal of Immunology, Dec. 1, 1996, vol. 157, 4918-4925.
Manzel et al. CpG-Oligodeoxynucleotide supports growth of IL-6 dependent 7TD1 murine hybridoma cells. Life Sciences, published Nov. 1997, vol. 62, No. 1, 23-27.
Klinman et al. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. USA, Apr. 1996, vol. 93, 2879-2883.
Raz et al. U.S. Appl. No. 60/048,793.
Chou et al., “Surrogate models for antimalarials,” In:Antimalarial Drugs, Peters and Richard (eds.), Springer Verlag Berlin, 1974, p. 281-329.
Corcoran et al., “Mechanism of action of antimicrobial and antitumor agents,” In:Antibiotics III, Springer Verlag, Berlin, 1975, p. 59-78.
Elslager et al., “Antimalarial and antischistosomal effects of proximal hydrazine and hydroxylamine analogs of chloroquine and quinacrine,”J. Org. Chem., 12:970-974, 1969.
Elslager et al., “Repository drugs. 8. Ester and amide congeners of amodiaquine, hydroxychloroquine, oxychloroquine, primaquine, quinacrine, and related substances as potential long-acting antimalarial agents,”J. Org. Chem., 12:600-607, 1969.
Ferrante et al., “Depression of human polymorphonuclear leucocyte function by anti-malarial drugs”Immunology, 58:125-130, 1986.
Foldes-Filep et al., “Mepacrine inhibits fMLP-induced activation of human neutrophil granulocytes, leukotrinene B4formation, and fMLP binding,”J. Leuk. Biol., 52:545-550, 1992.
Hannun, “Functions of ceramide in corrdinating cellular responses to stress,”Science, 274:1855-1859, 1996.
Hurst et al., “Differential effects of mepacrine, chloroquine and hydroxychloroquine on superoxide anion generation, phospholipid methylation and arachidonic acid release by human blood monocytes,”Biochem. Pharmacol., 35:3083-3089, 1986.
Jakobsen et al., “The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of plasmodium falciparum malaria parasites,”Trop. Med. Parasitol., 46(2):88-92, 1995.
Krakauer, “A sensitive, specific immunobioassay for quantification of human interleukin 6,”J. Immunoassay, 14:267-277, 1993.
Macfarlane and Manzel, “Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds,”J. Immunology, 160:1122-1131, 1998.
MacFarlane et al., “Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: evidence for blockade of apoptosis at a distal signalling step,”Immunology, 91:586-593, 1997.
Manzel et al., “CpG-oligodeoxynucleotide supports growth of IL-6-dependent 7TD1 murine hybridoma cells,”Life Science, 62:23-27, 1998.
Marquez et al., “Mechanism of ation of amoidoquine synthesis of its indoloquinoline analog,”J. Med. Chem., 15:36-39, 1972.
Mattsson et al., “Intracellular pathways involved in tumor necrosis factor-alpha release by human monocytes on stimulation with lipopolysaccharide or staphylococcal peptidoglycan are partly similar,”Joint Infectious Diseases, 173:212-218, 1996.
Papadopoulos et al., “Bioassay vs. immunoassay for quantification of interleukin-6 in biological fluids,”J. Clin. Lab Anal., 9:234-237, 1995.
Roberts et al., “The regulation of neutrophil phosphoipase A2by granulocyte-macrophage colony-stimulating factor and its role in priming superoxide production,”Brit. J. Haematol., 92: 804-814, 1996.
Sakuta et al., “Inhibition of SKF 525A and quinacrine of endogenous glibenclamide-sensitive K channels in follicle-enclosed Xenopus ocytes,”Eur. J. Pharmacol., 252:117-121, 1993.
Tamamizu et al., “Mutations in the M1 region of the nicotinic acetylcholing receptor alter the sensitivity to inhibition by Quinacrine,”Cell. Mol. Neurobiol., 15:427-438, 1995.

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