Methods for inhibiting bone loss using pyrolidine and piperidine

Details Methods for inhibiting bone loss using pyrolidine and piperidine Methods for inhibiting bone loss using pyrolidine and piperidine

1993-11-05

1995-04-18

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 514422, A61K 31445, A61K 3144, A61K 3140

Patent

active

054079470

ABSTRACT:
A method of inhibiting bone loss comprising administering to an animal an effective amount of a compound having the formula ##STR1## wherein: R.sup.1 and R.sup.2 are, independently, --H, --OH, halo, --OC.sub.1 -C.sub.17 alkyl, --OC.sub.3 -C.sub.6 cycloalkyl, --O(CO)C.sub.1 -C.sub.17 alkyl, --O(CO) aryl, --O(CO)O aryl, or --OSO.sub.2 -(n-butyl or n-pentyl);

REFERENCES:
patent: 5183814 (1993-02-01), Dukes
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Verm et al., "Synthesis of 3-aryl-1-(4-methoxy phenyl)-2-[4-(2-substituted aminoethoxy) phenyl]-L-propen-1-ones and benzopyran derivative," Indian J. of Chem., 32B, 239-243 (Feb. 1993).

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